|Title:||Vaccination of mice against Schistosoma bovis with a recombinant fatty acid binding protein from Fasciola hepatica||Authors:||López Abáne, J.
Pérez Arellano, José Luis
Hillyer, G. V.
|UNESCO Clasification:||310907 Patología||Keywords:||Mouse-Schistosoma Bovis
|Issue Date:||2000||Journal:||Veterinary Parasitology||Abstract:||Two strains of mice (NMRI and C57/BL) were each immunized with a 15 kDa recombinant Fasciola hepatica fatty acid binding protein (FABP) (Fh15) and challenged percutaneously with Schistosoma bovis cercariae, C57/BL mice immunized with Fh15 had significant reductions in S. bovis worm burden recoveries (72% reductions over controls). When using NMRI mice, Fh15 in Freund's adjuvant failed to induce significant protection against S. bovis. In C57/BL mice, only antibodies to the IgG2a isotype increased after the second immunization and remained high through 8 weeks of S. bovis infection, This is the first time that a heterologous recombinant molecule from F. hepatica has been used in vaccination against S. bovis, obtaining a significant reduction in the number of worms in C57/BL mice.||URI:||http://hdl.handle.net/10553/74149||ISSN:||0304-4017||Source:||Veterinary Parasitology [ISSN 0304-4017], v. 91 (1-2), p. 33-42, (Julio 2000)|
|Appears in Collections:||Artículos|
WEB OF SCIENCETM
checked on Sep 26, 2021
checked on Sep 11, 2021
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.