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Title: Immunopathological Study of Parasitic Cholangitis in Dolphins
Authors: Jáber Mohamad, José Raduán 
Pérez, José
Zafra Leva,Rafael 
Suárez Bonnet, Alejandro 
Quesada Canales, Ildefonso Óscar 
Fernández Rodríguez, Antonio Jesús 
González Pérez, Jorge Francisco 
Carrascosa Iruzubieta, Conrado Javier 
UNESCO Clasification: 310907 Patología
3105 Peces y fauna silvestre
Keywords: Cholangitis
Issue Date: 2013
Journal: Journal of Comparative Pathology 
Abstract: This paper describes the immunophenotype of cellular inflammatory infiltrates in chronic cholangitis in six common dolphins (Delphinus delphis), four striped dolphins (Stenella coeruleoalba), three Atlantic spotted dolphins (Stenella frontalis) and one pygmy sperm whale (Kogia Breviceps) found stranded along the coasts of the Canary Islands (Spain). A panel of 5 antibodies previously tested in dolphins (anti-CD3, -IgG, -MHC class II, -S100 protein and -lysozyme) were used. The present work also reports cross reactivity with dolphin antigens of two antibodies not used to date in dolphins (anti-mouse iNOS and anti-mouse Foxp3). The most common type of cholangitis found was chronic granulomatous cholangitis, associated with the presence of the parasite Campula spp., or its eggs in bile ducts. The cellular composition of the hepatic inflammatory infiltrate associated to chronic parasitic cholangitis was closely similar to that found in the cortex of control lymph nodes, including the presence of S100(+) and MHC class II(+) dendritic-like cells in lymphoid follicles and interfollicular areas. Only occasional macrophages expressed iNOS, whereas Foxp3(+) lymphocytes were not found in any of the lesions described in the different types of cholangitis.
ISSN: 0021-9975
DOI: 10.1016/j.jcpa.2012.11.170
Source: Journal of Comparative Pathology [ISSN 0021-9975], v. 148 (1), p. 88, (Enero 2013)
Appears in Collections:Actas de congresos
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