Force platform analysis of the effect of intrarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF in osteoarthritic dogs

Abstract

Adipose-derived mesenchymal stem cell (aMSC) therapy in regenerative medicine is a rapidly growing area of research and is currently also being used to treat osteoarthritis (OA). Force platform analysis has been consistently used to verify the efficacy of different therapeutic strategies for the treatment of OA in dogs, but never with aMSC. Recent investigations have shown that growth factors contained in platelet-rich plasma (PRGF) act as vehicles and even potentiators of the effect of aMSCs. The purpose of this study was to use force platform kinetic analysis to evaluate the effect of a single intraarticular injection of aMSC in 8 dogs with OA of hip joints by measuring peak vertical force (PVF) and vertical impulse (VI), which represent maximal weight bearing and distribution of forces through time, respectively