Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/73416
Título: Determination of 5-fluorocytosine, 5-fluorouracil, and 5-fluorouridine in hospital wastewater by liquid chromatography–mass spectrometry
Autores/as: Škvára, Pavel
Santana-Viera, Sergio 
Montesdeoca-Esponda, Sarah 
Mordačíková, Erika
Santana-Rodríguez, José Juan 
Vojs Staňová, Andrea
Clasificación UNESCO: 330810 Tecnología de aguas residuales
2391 Química ambiental
2301 química analítica
Palabras clave: Cytostatic Compounds
Sample Pretreatment
Tandem Mass Spectrometry
Wastewater Samples
Fecha de publicación: 2020
Proyectos: Slovak Research and Development Agency (APVV-16-0124)
Grant of the Comenius University (UK/193/2018)
Estrategias Para El Control y Remediación Natural de Compuestos Orgánicos Emergentes en Aguas Residuales. Impacto en El Medio Marino. 
Ministry of Education, Youth and Sports of the Czech Republic as part of project “CENAKVA” (LM2018099)
Publicación seriada: Journal of Separation Science 
Resumen: Chemotherapeutics are pharmaceutical compounds the occurrence of which in the environment is of growing concern because of the increase in treatments against cancer diseases. They can reach the aquatic ecosystems after passing through wastewater treatment plants without complete removal. One of the most frequently used chemotherapeutics is 5-fluorouracil which exhibits a strong cytostatic effect. In this paper, an analytical methodology was developed, validated, and applied to determine 5-fluorouracil, its precursor, 5-fluorocytosine, and its major active metabolite, 5-fluorouridine, in hospital wastewater samples. Due to the expected low concentrations after dilution and interferences present in such a complex matrix, a very selective and sensitive detection method is required. Moreover, an extraction method must be implemented prior to the determination in order to purify the sample extract and preconcentrate the target analytes at micrograms per liter concentration levels. Solid-phase extraction followed by liquid chromatography with tandem mass spectrometry was the combination of choice and all included parameters were studied. Under optimized conditions for wastewater samples analysis, recoveries from 63 to 108% were obtained, while intraday and interday relative standard deviations never exceeded 20 and 25%, respectively. Limits of detection between 61 and 620 ng/L were achieved. Finally, the optimized method was applied to samples from hospital wastewater effluents.
URI: http://hdl.handle.net/10553/73416
ISSN: 1615-9306
DOI: 10.1002/jssc.202000144
Fuente: Journal of Separation Science [ISSN 1615-9306], v. 43(15), p. 3074-3082
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