Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/72766
Title: Enzymatic degradation study of PLA-based composite scaffolds
Authors: Donate, Ricardo 
Monzón, Mario 
Alemán-Domínguez, María Elena 
Ortega, Zaida 
UNESCO Clasification: 3312 Tecnología de materiales
3313 Tecnología e ingeniería mecánicas
3314 Tecnología médica
Keywords: Polylactic acid
PLA bone tissue engineering
Bone tissue engineering
Proteinase K
Issue Date: 2020
Project: Mejora de la Biofuncionalidad de Scaffolds Polimericos Obtenidos Por Fabricacion Aditiva 
Journal: Reviews on Advanced Materials Science 
Abstract: Disadvantages in the use of polylactic acid (PLA) as a base material for Tissue Engineering applications include the low osteoconductivity of this biomaterial, its acidic degradation and the deficient cellular adhesion on its surface. In order to counteract these drawbacks, calcium carbonate (CaCO3) and β-tricalcium phosphate (Ca3(PO4)2, β-TCP) were proposed in this work as additives of PLA-based support structures. Composite scaffolds (PLA:CaCO3:β-TCP 95:2.5:2.5) manufactured by fused deposition modeling (FDM) were tested under enzymatic degradation using proteinase K enzymes to assess the modification of their properties in comparison with neat PLA scaffolds. The samples were characterized before and after the degradation test by optical microscopy, scanning electron microscopy, compression testing and thermogravimetric and calorimetric analysis. According to the results, the combination of the PLA matrix with the proposed additives increases the degradation rate of the 3D printed scaffolds, which is an advantage for the application of the composite scaffold in the field of Tissue Engineering. The higher degradation rate of the composite scaffolds could be explained by the release of the additive particles and the statistically higher microporosity of these samples compared to the neat PLA ones.
URI: http://hdl.handle.net/10553/72766
ISSN: 1605-8127
DOI: 10.1515/rams-2020-0005
Source: Reviews on Advanced Materials Science [ISSN 1605-8127], v.59 (1), p. 170-175
Appears in Collections:Artículos
Thumbnail
Adobe PDF (8,31 MB)
Show full item record

SCOPUSTM   
Citations

31
checked on Nov 3, 2024

WEB OF SCIENCETM
Citations

31
checked on Nov 3, 2024

Page view(s)

129
checked on Jan 27, 2024

Download(s)

95
checked on Jan 27, 2024

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.