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Title: Supplementation with a mango leaf extract (Zynamite®) in combination with quercetin attenuates muscle damage and pain and accelerates recovery after strenuous damaging exercise
Authors: Martin-Rincon, Marcos 
Gelabert-Rebato, Miriam 
Galvan-Alvarez, Victor 
Gallego Selles, Ángel 
Martinez Canton, Miriam 
López Ríos,Laura 
Wiebe, Julia C.
Martín Rodríguez, Saúl 
Arteaga Ortiz, Rafael Ángel 
Dorado, Cecilia 
Pérez Regalado, Sergio 
Santana, Alfredo 
Morales-Alamo, David 
Calbet, Jose A.L. 
UNESCO Clasification: 241106 Fisiología del ejercicio
32 Ciencias médicas
2411 Fisiología humana
Keywords: Antioxidant Supplementation
Eccentric Exercise
Ergogenic Aids, et al
Issue Date: 2020
Project: Identificacion E Integracion de Nuevos Factores Moleculares, Fisiologicosy Bioelectricos Determinantes Del Rendimiento en El Ejercicio de Sprint 
Desarrolloy Caracterización Molecular de Un Nuevo Modelo de Precondicionamiento Remoto 
Journal: Nutrients 
Abstract: Prolonged or unusual exercise may cause exercise-induced muscle damage (EIMD). To test whether Zynamite®, a mango leaf extract rich in the natural polyphenol mangiferin, administered in combination with quercetin facilitates recovery after EIMD, 24 women and 33 men were randomly assigned to two treatment groups matched by sex and 5 km running performance, and ran a 10 km race followed by 100 drop jumps to elicit EIMD. One hour before the competition, and every 8 hours thereafter for 24 hours, they ingested placebo (728 mg of maltodextrin) or 140 mg of Zynamite® combined with 140 mg of quercetin (double-blind). Although competition times were similar, polyphenol supplementation attenuated the muscle pain felt after the competition (6.8 ± 1.5 and 5.7 ± 2.2 a.u., p = 0.035) and the loss of jumping performance (9.4 ± 11.5 and 3.9 ± 5.2%, p = 0.036; p = 0.034) and mechanical impulse (p = 0.038) 24 hours later. The polyphenols attenuated the increase of serum myoglobin and alanine aminotransferase in men, but not in women (interaction p < 0.05). In conclusion, a single dose of 140 mg Zynamite® combined with 140 mg of quercetin, administered one hour before competition, followed by three additional doses every eight hours, attenuates muscle pain and damage, and accelerates the recovery of muscle performance.
ISSN: 2072-6643
DOI: 10.3390/nu12030614
Source: Nutrients [ISSN 2072-6643], v. 12 (3), 614
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