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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/70087
DC FieldValueLanguage
dc.contributor.authorOramas-Royo, Sandra-
dc.contributor.authorLópez-Rojas, Priscila-
dc.contributor.authorAmesty, Ángel-
dc.contributor.authorGutiérrez, David-
dc.contributor.authorFlores, Ninoska-
dc.contributor.authorMartín-Rodríguez, Patricia-
dc.contributor.authorFernández-Pérez, Leandro-
dc.contributor.authorEstévez-Braun, Ana-
dc.date.accessioned2020-02-05T12:52:20Z-
dc.date.available2020-02-05T12:52:20Z-
dc.date.issued2019-
dc.identifier.issn1420-3049-
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/70087-
dc.description.abstractA series of 34 1,2,3-triazole-naphthoquinone conjugates were synthesized via copper-catalyzed cycloaddition (CuAAC). They were evaluated for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum and against three different tumor cell lines (SKBr-3, MCF-7, HEL). The most active antimalarial compounds showed a low antiproliferative activity. Simplified analogues were also obtained and some structure–activity relationships were outlined. The best activity was obtained by compounds 3s and 3j, having IC50 of 0.8 and 1.2 μM, respectively. Molecular dockings were also carried on Plasmodium falciparum enzyme dihydroorotate dehydrogenase (PfDHODH) in order to rationalize the results.-
dc.languageeng-
dc.relationDesarrollo Preclínico de Nuevas Estructuras Bioactivas Moduladoras de Las Actividades Oncogénicas de Stat3/5 O de Los Receptores de Estrógenos-
dc.relation.ispartofMolecules-
dc.sourceMolecules [1420-3049], v. 24 (21)-
dc.subject32 Ciencias médicas-
dc.subject.other1,2,3-Triazole-Naphthoquinones-
dc.subject.otherCopper-Catalyzed Cycloaddition-
dc.subject.otherDocking-
dc.subject.otherMalaria-
dc.subject.otherPlasmodium Falciparum-
dc.titleSynthesis and antiplasmodial activity of 1,2,3-triazole-naphthoquinone conjugates-
dc.typeinfo:eu-repo/semantics/article-
dc.typeArticle-
dc.identifier.doi10.3390/molecules24213917-
dc.identifier.scopus85074418775-
dc.identifier.isi000498055500106-
dc.contributor.authorscopusid36468756400-
dc.contributor.authorscopusid57200365358-
dc.contributor.authorscopusid14024036100-
dc.contributor.authorscopusid12760276700-
dc.contributor.authorscopusid16506822400-
dc.contributor.authorscopusid36604772400-
dc.contributor.authorscopusid6506777525-
dc.contributor.authorscopusid6701825073-
dc.identifier.eissn1420-3049-
dc.identifier.issue21-
dc.relation.volume24-
dc.investigacionCiencias de la Salud-
dc.type2Artículo-
dc.contributor.daisngid7533230-
dc.contributor.daisngid13205981-
dc.contributor.daisngid3211275-
dc.contributor.daisngid3028397-
dc.contributor.daisngid2469466-
dc.contributor.daisngid3922169-
dc.contributor.daisngid30259663-
dc.contributor.daisngid425077-
dc.description.numberofpages22-
dc.utils.revisionSí-
dc.contributor.wosstandardWOS:Oramas-Royo, S-
dc.contributor.wosstandardWOS:Lopez-Rojas, P-
dc.contributor.wosstandardWOS:Amesty, A-
dc.contributor.wosstandardWOS:Gutierrez, D-
dc.contributor.wosstandardWOS:Flores, N-
dc.contributor.wosstandardWOS:Martin-Rodriguez, P-
dc.contributor.wosstandardWOS:Fernandez-Perez, L-
dc.contributor.wosstandardWOS:Estevez-Braun, A-
dc.date.coverdateNoviembre 2019-
dc.identifier.ulpgcSíes
dc.description.sjr0,698
dc.description.jcr3,267
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.project.principalinvestigatorFernández Pérez, Leandro Francisco-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-2378-3242-
crisitem.author.orcid0000-0001-7802-465X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameMartín Rodríguez, Patricia-
crisitem.author.fullNameFernández Pérez, Leandro Francisco-
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