Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/70087
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Oramas-Royo, Sandra | - |
| dc.contributor.author | López-Rojas, Priscila | - |
| dc.contributor.author | Amesty, Ángel | - |
| dc.contributor.author | Gutiérrez, David | - |
| dc.contributor.author | Flores, Ninoska | - |
| dc.contributor.author | Martín-Rodríguez, Patricia | - |
| dc.contributor.author | Fernández-Pérez, Leandro | - |
| dc.contributor.author | Estévez-Braun, Ana | - |
| dc.date.accessioned | 2020-02-05T12:52:20Z | - |
| dc.date.available | 2020-02-05T12:52:20Z | - |
| dc.date.issued | 2019 | - |
| dc.identifier.issn | 1420-3049 | - |
| dc.identifier.other | Scopus | - |
| dc.identifier.uri | http://hdl.handle.net/10553/70087 | - |
| dc.description.abstract | A series of 34 1,2,3-triazole-naphthoquinone conjugates were synthesized via copper-catalyzed cycloaddition (CuAAC). They were evaluated for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum and against three different tumor cell lines (SKBr-3, MCF-7, HEL). The most active antimalarial compounds showed a low antiproliferative activity. Simplified analogues were also obtained and some structure–activity relationships were outlined. The best activity was obtained by compounds 3s and 3j, having IC50 of 0.8 and 1.2 μM, respectively. Molecular dockings were also carried on Plasmodium falciparum enzyme dihydroorotate dehydrogenase (PfDHODH) in order to rationalize the results. | - |
| dc.language | eng | - |
| dc.relation | Desarrollo Preclínico de Nuevas Estructuras Bioactivas Moduladoras de Las Actividades Oncogénicas de Stat3/5 O de Los Receptores de Estrógenos | - |
| dc.relation.ispartof | Molecules | - |
| dc.source | Molecules [1420-3049], v. 24 (21) | - |
| dc.subject | 32 Ciencias médicas | - |
| dc.subject.other | 1,2,3-Triazole-Naphthoquinones | - |
| dc.subject.other | Copper-Catalyzed Cycloaddition | - |
| dc.subject.other | Docking | - |
| dc.subject.other | Malaria | - |
| dc.subject.other | Plasmodium Falciparum | - |
| dc.title | Synthesis and antiplasmodial activity of 1,2,3-triazole-naphthoquinone conjugates | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.3390/molecules24213917 | - |
| dc.identifier.scopus | 85074418775 | - |
| dc.identifier.isi | 000498055500106 | - |
| dc.contributor.authorscopusid | 36468756400 | - |
| dc.contributor.authorscopusid | 57200365358 | - |
| dc.contributor.authorscopusid | 14024036100 | - |
| dc.contributor.authorscopusid | 12760276700 | - |
| dc.contributor.authorscopusid | 16506822400 | - |
| dc.contributor.authorscopusid | 36604772400 | - |
| dc.contributor.authorscopusid | 6506777525 | - |
| dc.contributor.authorscopusid | 6701825073 | - |
| dc.identifier.eissn | 1420-3049 | - |
| dc.identifier.issue | 21 | - |
| dc.relation.volume | 24 | - |
| dc.investigacion | Ciencias de la Salud | - |
| dc.type2 | Artículo | - |
| dc.contributor.daisngid | 7533230 | - |
| dc.contributor.daisngid | 13205981 | - |
| dc.contributor.daisngid | 3211275 | - |
| dc.contributor.daisngid | 3028397 | - |
| dc.contributor.daisngid | 2469466 | - |
| dc.contributor.daisngid | 3922169 | - |
| dc.contributor.daisngid | 30259663 | - |
| dc.contributor.daisngid | 425077 | - |
| dc.description.numberofpages | 22 | - |
| dc.utils.revision | Sí | - |
| dc.contributor.wosstandard | WOS:Oramas-Royo, S | - |
| dc.contributor.wosstandard | WOS:Lopez-Rojas, P | - |
| dc.contributor.wosstandard | WOS:Amesty, A | - |
| dc.contributor.wosstandard | WOS:Gutierrez, D | - |
| dc.contributor.wosstandard | WOS:Flores, N | - |
| dc.contributor.wosstandard | WOS:Martin-Rodriguez, P | - |
| dc.contributor.wosstandard | WOS:Fernandez-Perez, L | - |
| dc.contributor.wosstandard | WOS:Estevez-Braun, A | - |
| dc.date.coverdate | Noviembre 2019 | - |
| dc.identifier.ulpgc | Sí | es |
| dc.description.sjr | 0,698 | |
| dc.description.jcr | 3,267 | |
| dc.description.sjrq | Q1 | |
| dc.description.jcrq | Q2 | |
| dc.description.scie | SCIE | |
| item.grantfulltext | open | - |
| item.fulltext | Con texto completo | - |
| crisitem.project.principalinvestigator | Fernández Pérez, Leandro Francisco | - |
| crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
| crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
| crisitem.author.dept | Departamento de Morfología | - |
| crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
| crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
| crisitem.author.dept | Departamento de Ciencias Clínicas | - |
| crisitem.author.orcid | 0000-0002-2378-3242 | - |
| crisitem.author.orcid | 0000-0001-7802-465X | - |
| crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
| crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
| crisitem.author.fullName | Martín Rodríguez, Patricia | - |
| crisitem.author.fullName | Fernández Pérez, Leandro Francisco | - |
| Appears in Collections: | Artículos | |
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