Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/70083
Title: The analysis of bifenox and dichlobenil toxicity in selected microorganisms and human cancer cells
Authors: Jabłońska-Trypuć, Agata
Wydro, Urszula
Serra-Majem, Lluis 
Wołejko, Elżbieta
Butarewicz, Andrzej
UNESCO Clasification: 32 Ciencias médicas
Keywords: Bacteria
Fungi
Herbicides
Zr-75-1 Cells
Issue Date: 2019
Journal: International Journal of Environmental Research and Public Health 
Abstract: Bifenox and Dichlobenil belong to the commonly used in Poland in agriculture group of herbicides and their residues are often detected in the environment. They are poorly known regarding their possible carcinogenic and antibacterial effect at the cellular level. Therefore, we decided to study their activity in bacterial strains Aliivibrio fisheri, E. coli, P. aeruginosa, and C. albicans (yeast) and human cancer ZR-75-1 cells. Compounds under study exhibit stimulatory effect on analyzed bacterial strains. The study performed on mammalian cells better reflects the influence of environmental pollutants on human organism, therefore we evaluated the effect of herbicides on ZR-75-1 cells. Cells viability, apoptosis and selected oxidative stress parameters in ZR-75-1 cells were investigated. Both analyzed substances exhibit stimulatory effects on analyzed parameters, however they do not stimulate apoptosis which correlate positively with the induction of oxidative stress. Bifenox and Dichlobenil enhance oxidative stress parameters by the generation of high levels of ROS, which can lead to their adaptation and resistance to the standard treatment regimen.
URI: http://hdl.handle.net/10553/70083
ISSN: 1661-7827
DOI: 10.3390/ijerph16214137
Source: International Journal Of Environmental Research And Public Health [ISSN 1661-7827], v. 16 (21), (Noviembre 2019)
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