Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/70070
Title: Role of bulge epidermal stem cells and TSLP signaling in psoriasis
Authors: Gago-Lopez, Nuria
Mellor, Liliana F.
Megías, Diego
Martín-Serrano, Guillermo
Izeta, Ander
Jimenez, Francisco
Wagner, Erwin F.
UNESCO Clasification: 320106 Dermatología
Keywords: Epidermal Hyper-Proliferation
Hair Follicle Stem Cells
Lineage Tracing
Psoriasis
Thymic Stromal Lymphopoietin
Issue Date: 2019
Journal: EMBO Molecular Medicine 
Abstract: Psoriasis is a common inflammatory skin disease involving a cross-talk between epidermal and immune cells. The role of specific epidermal stem cell populations, including hair follicle stem cells (HF-SCs) in psoriasis is not well defined. Here, we show reduced expression of c-JUN and JUNB in bulge HF-SCs in patients with scalp psoriasis. Using lineage tracing in mouse models of skin inflammation with inducible deletion of c-Jun and JunB, we found that mutant bulge HF-SCs initiate epidermal hyperplasia and skin inflammation. Mechanistically, thymic stromal lymphopoietin (TSLP) was identified in mutant cells as a paracrine factor stimulating proliferation of neighboring non-mutant epidermal cells, while mutant inter-follicular epidermal (IFE) cells are lost over time. Blocking TSLP in psoriasis-like mice reduced skin inflammation and decreased epidermal proliferation, VEGF alpha expression, and STAT5 activation. These findings unravel distinct roles of HF-SCs and IFE cells in inflammatory skin disease and provide novel mechanistic insights into epidermal cell interactions in inflammation.
URI: http://hdl.handle.net/10553/70070
ISSN: 1757-4676
DOI: 10.15252/emmm.201910697
Source: Embo Molecular Medicine [ISSN 1757-4676], v. 11 (11), (Noviembre 2019)
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