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Title: Cardiovascular risk factors and arterial thrombotic events in congenital heart disease patients
Authors: Martínez-Quintana, Efrén 
Rodríguez-Hernández, Juan Lizandro
Rodríguez-González, Fayna
Riaño-Ruiz, Marta
Fraguela-Medina, Carla
Girolimetti, Angela
Jiménez-Rodríguez, Sara
UNESCO Clasification: 320501 Cardiología
Keywords: Acute Coronary Events
Cardiovascular Risk Factors
Congenital Heart Disease
Issue Date: 2019
Journal: International Journal of Clinical Practice 
Abstract: Introduction: As congenital patients get older, it can be hypothesised that cardiovascular risk factors increase. Methods: Retrospective study of congenital heart disease (CHD) patients attended between January 2008 and September 2018. Cardiovascular risk factors, myocardial infarction, stroke, peripheral vascular disease, and analytical data such as serum glucose and lipid profile were determined. Results: Eight hundred and eighteen CHD patients and 1955 control patients matched for age and sex were studied. CHD patients were distributed in simple (462 patients), moderate (228 patients) and great (128 patients) complexity. Median age in CHD patients was 33 (25-41) years old and 56% were male. CHD patients were significantly more hypertensive and diabetic but less dyslipidemic and smokers than patients in the control group. Twenty-seven (3.3%) CHD patients had an arterial thrombotic event: 3 coronary, 22 neurological and 2 peripheral vascular disease. No significant differences were seen in the incidence of myocardial infarction between the control and the CHD groups. However CHD patients had a significant higher incidence of arterial thrombotic events (coronary, neurological and peripheral vascular events) at the expense of strokes and transient ischaemic attacks (22 vs 2 events in CHD and control patients, respectively). Also, no significant differences were seen in age, sex, BMI, arterial hypertension, diabetes mellitus, dyslipidemia, smoking habit, serum glucose, total and LDL cholesterol, statin treatment, myocardial infarction and arterial thrombotic events according to CHD complexity. Being older and having arterial hypertension, diabetes mellitus, dyslipidemia and smoking habit were more frequent among CHD patients with arterial thrombosis. Conclusions: Congenital heart diseases are more hypertensive and diabetic but less dyslipemic and smokers than patients in the control group. CHD patients have a higher incidence of neurological events but not of myocardial infarction in relation to the control population.
ISSN: 1368-5031
DOI: 10.1111/ijcp.13378
Source: International Journal of Clinical Practice [ISSN 1368-5031], v. 73 (9), p. 1-8
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