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Title: High sleep variability predicts a blunted weight loss response and short sleep duration a reduced decrease in waist circumference in the PREDIMED-Plus Trial
Authors: Papandreou, Christopher
Bulló, Mónica
Díaz-López, Andrés
Martínez-González, Miguel A.
Corella, Dolores
Castañer, Olga
Vioque, Jesus
Romaguera, Dora
Martínez, Alfredo J.
Pérez-Farinós, Napoleón
López-Miranda, Jose
Estruch, Ramon
Bueno-Cavanillas, Aurora
Alonso-Gómez, Angel
Tur, Josep A.
Tinahones, Francisco J.
Serra-Majem, Luis 
Martin, Vicente
Lapetra, Jose
Vazquez, Clotilde
Pintó, Xavier
Vidal, Josep
Damiel, Lidia
Delgado-Rodriguez, Miguel
Ros, Emilio
Abete, Itziar
Barón-López, Javier
Garcia-Arellano, Ana
Sorli, Jose V.
Babio, Nancy
Schröder, Helmut
Toledo, Estefania
Fitó, Montse
Salas-Salvadó, Jordi
UNESCO Clasification: 3206 Ciencias de la nutrición
Keywords: Body-Mass Index
Abdominal Obesity
Midlife Women
Association, et al
Issue Date: 2019
Project: Efecto de la Dieta Mediterránea Hopocalórica y Promoción de la Actividad Física en Prevención Primaria Cardiovascular.Estudio Piloto Sobre Marcadores Intermedios. 
Efecto de Una Pérdida de Peso Con Dieta Mediterránea Hipocalórica y Promoción de la Actividad Física en la Prevención Primaria Cardiovascular 
Journal: International Journal of Obesity 
Abstract: Background: Whether short sleep duration or high sleep variability may predict less weight loss and reduction in measures of adiposity in response to lifestyle interventions is unknown. The aim of this study was to compare the 12-month changes in weight and adiposity measures between those participants with short or adequate sleep duration and those with low or high sleep variability (intra-subject standard deviation of the sleep duration) in PREvención con DIeta MEDiterránea (PREDIMED)-Plus, a primary prevention trial based on lifestyle intervention programs. Methods: Prospective analysis of 1986 community-dwelling subjects (mean age 65 years, 47% females) with overweight/obesity and metabolic syndrome from the PREDIMED-Plus trial was conducted. Accelerometry-derived sleep duration and sleep variability and changes in average weight, body mass index (BMI), and waist circumference (WC) attained after 12-month interventions were analyzed. Results: The adjusted difference in 12-month changes in weight and BMI in participants in the third tertile of sleep variability was 0.5 kg (95% CI 0.1 to 0.9; p = 0.021) and 0.2 kg/m2 (0.04 to 0.4; p = 0.015), respectively, as compared with participants in the first tertile. The adjusted difference in 12-month changes from baseline in WC was −0.8 cm (−1.5 to −0.01; p = 0.048) in participants sleeping <6 h, compared with those sleeping between 7 and 9 h. Conclusions: Our findings suggest that the less variability in sleep duration or an adequate sleep duration the greater the success of the lifestyle interventions in adiposity.
ISSN: 0307-0565
DOI: 10.1038/s41366-019-0401-5
Source: International Journal Of Obesity[ISSN 0307-0565],v. 44 (2), p. 330-339, (Febrero 2020)
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