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Title: Pyogenic liver abscesses due to Escherichia coli are still related to worse outcomes
Authors: Ruiz Hernández, José Juan 
Conde Martel, Alicia 
Serrano-Fuentes, Miriam
Hernández-Meneses, Marta
Merlán-Hermida, Alejandro
Rodríguez-Pérez, Alba
Marchena Gómez, Joaquín 
UNESCO Clasification: 320506 Nefrología
Keywords: Escherichia Coli
Pyogenic Liver Abscess
Issue Date: 2019
Journal: Irish Journal of Medical Science 
Abstract: Background: In western countries, there has been a gradual shift from Escherichia coli to Klebsiella pneumoniae as an emerging pathogen isolated from pyogenic liver abscesses (PLA). Aims: To compare outcomes between patients with Escherichia coli liver abscesses and non–Escherichia coli liver abscesses in terms of mortality. Methods: One hundred nine-three consecutive hospital admissions of Pyogenic liver abscesses were analyzed, mean age 66.9 years old (± 13.6), 112 men (58%). The sample was divided into two groups: E. coli liver abscesses and non–E. coli liver abscesses. The etiologic, clinical, and microbiologic characteristics; therapeutic options; and outcomes, in terms of morbidity and mortality, between E. coli and non–E. coli liver abscesses were compared. In-hospital mortality, as outcome variable, was analyzed in a multivariate analysis. Results: Fifty-seven episodes of PLA (29.5%) corresponded to E. coli infections, and 136 (70.5%) to non–E. coli infections. Patients with E. coli PLA were more likely to have jaundice, polymicrobial isolation (57.1% vs 21.6%, p < 0.001), biliary origin (71.9% vs 39%, p < 0.001), and septic shock (38.6% vs 12.5%, p < 0.001). Antibiotic therapy alone, without percutaneous drainage, was less common in the E. coli PLA group (5.3% vs 18.4%, p = 0.018). These patients also showed a higher mortality (28.1% vs 11%, p = 0.003). In multivariate analysis, E. coli isolation PLA adjusted remained as an independent factor of mortality (OR 2.6, 95%CI 1.04–6.56, p = 0.041). Conclusions: E. coli liver abscess may preclude a worse outcome than other microbiological agents, including the development of septic shock and mortality. Aggressive management must be considered.
ISSN: 0021-1265
DOI: 10.1007/s11845-019-02041-4
Source: Irish Journal of Medical Science [ISSN 0021-1265]
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