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Title: Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making
Authors: Paslakis, Georgios
Agüera, Zaida
Granero, Roser
Sánchez, Isabel
Riesco, Nadine
Jiménez-Murcia, Susana
Fernández-García, Jose C.
Garrido-Sánchez, Lourdes
Tinahones, Francisco J.
Casanueva, Felipe F.
Baños, Rosa M.
Botella, Cristina
Crujeiras, Ana B.
Torre, Rafael de la
Fernández-Real, Jose M.
Frühbeck, Gema
Ortega, Francisco J.
Rodríguez, Amaia
Serra Majem, Luis 
Fitó, Montserrat
Menchón, José M.
Fernández-Aranda, Fernando
UNESCO Clasification: 320610 Enfermedades de la nutrición
Keywords: Anorexia Nervosa
Appetite Regulation
Neuropsychological Performance
Issue Date: 2019
Journal: Molecular and Cellular Endocrinology 
Abstract: Anorexia nervosa (AN) is a severe eating disorder accompanied by alterations in endocrinological circuits and deficits in neuropsychological performance. In this study, a series of appetite-regulating hormones (ghrelin, leptin, cholecystokinin, PYY, adiponectin, and visfatin) were measured under fasting conditions in female patients with AN and female healthy controls. All of the participants also underwent a battery of neuropsychological assessment [namely the Iowa Gambling Task (IGT), the Wisconsin Card Sorting Test (WCST), and the Stroop Color and Word Test (SCWT)]. As the main finding, we found that higher ghrelin levels predict better performance in the IGT. Ghrelin may be a putative mediator of decision-making, a finding that has not been described so far. The role of ghrelin in decision-making can only be described as speculative, as there are hardly any additional evidence-based data published up to date. Further studies are warranted.
ISSN: 0303-7207
DOI: 10.1016/j.mce.2019.04.021
Source: Molecular And Cellular Endocrinology [ISSN 0303-7207], v. 497, (Noviembre 2019)
Appears in Collections:Reseña
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