Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/69913
Title: Feasibility of a deep hyperthermia and radiotherapy programme for advanced tumors: first Spanish experience
Authors: Lloret Sáez-Bravo, Marta 
García-Cabrera, L.
Hernandez, A. 
Santana, N.
López-Molina, L.
Lara, P. C.
UNESCO Clasification: 320101 Oncología
Keywords: Advanced Tumors
Hyperthermia
Radiotherapy
Issue Date: 2019
Journal: Clinical and Translational Oncology 
Abstract: Background: Hyperthermia (HT) is used to increase the temperature of the tumor-sensitizing cells to the effects of radiation/chemotherapy. We aimed to assess the feasibility, tolerability and safety of hyperthermia treatment in a Radiation Oncology Department. Methods: Between June 2015 and June 2017, 106 patients and a total of 159 tumor lesions were included in a prospective study (EudraCT 2018-001089-40) of HT concomitant with radiotherapy (RT). Systemic treatment was accepted. HT was given twice a week, 60 min per session, during RT treatment by a regional capacitive device (HY-DEEP 600WM system) at 13.56 MHz radiofrequency. Results: Most lesions (138 cases, 86.8%) received all HT sessions planned. Thirteen lesions (12 patients) withdrew treatment due to grade ≥3 QMHT toxicity. All these 12 patients completed the prescribed radiotherapy and/or systemic treatment. Conclusions: Regional hyperthermia is a feasible and safe technique to be used in combination with radiotherapy and systemic treatment.
URI: http://hdl.handle.net/10553/69913
ISSN: 1699-048X
DOI: 10.1007/s12094-019-02097-9
Source: Clinical and Translational Oncology [ISSN 1699-048X], v. 21 (12), p. 1771-1775
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