Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/69900
Title: Accuracy of CAPRA-S Score for Predicting Long-Term Biochemical Progression After Radical Prostatectomy
Authors: Hernández Hernández, Casandra
Kim Lee, David
Sánchez Pérez, Miriam
Hernández Escobar, Sandra
UNESCO Clasification: 320713 Oncología
Keywords: Disease Progression
Prostate Cancer
Prostate Neoplasms
Recurrence
Risk Calculator
Issue Date: 2019
Journal: Clinical Genitourinary Cancer 
Abstract: The Cancer of the Prostate Risk Assessment Postsurgical (CAPRA-S) score is a tool to stratify patients into groups according to their risk for biochemical recurrence after radical prostatectomy. Retrospective analysis was performed of data from 479 patients. The CAPRA-S score is a useful tool in patients to classify the risk of long-term biochemical progression of patients, thus helping decide if adjuvant treatment should be required.Background: The Cancer of the Prostate Risk Assessment Postsurgical (CAPRA-S) score is a tool to stratify patients into groups according to their risk for biochemical recurrence after radical prostatectomy. The aim of this study was to assess the accuracy of the CAPRA-S score for predicting biochemical progression at 5 and 10 years in our cohort of patients after radical prostatectomy. Patients and Methods: Between June 2004 and December 2015, radical prostatectomy was performed as the main treatment option for patients with localized prostate cancer. Patients who had received adjuvant or neoadjuvant treatment were excluded from this study. Biochemical progression after radical prostatectomy was considered in patients by prostate-specific antigen (PSA) > 0.1 ng/mL after surgery (biochemical persistence) and by at least 2 determinations of PSA > 0.2 ng/mL in those patients with initial undetectable postoperative PSA any time during their follow-up (biochemical failure). Cox proportional hazard model and Kaplan-Meier analysis were used for the statistical analysis. Results: Of 531 patients who underwent radical prostatectomy, 479 met the inclusion criteria. Mean follow-up was 85 months (min-max, 13-153 months). The rate of biochemical progression -free survival at 10 years was 84.2%, 55.1%, and 32.8%, respectively, for high-, intermediate-, and low-risk patients according to the CAPRA-S score. The concordance index for CAPRA-S predicting biochemical progression at 5 years was 0.71 and at 10 years was 0.70. Conclusion: The CAPRA-S score is a useful and easy-to-use tool in patients after radical prostatectomy to classify their risk for biochemical progression, thus helping decide if adjuvant treatment should be required.
URI: http://hdl.handle.net/10553/69900
ISSN: 1558-7673
DOI: 10.1016/j.clgc.2019.03.014
Source: Clinical Genitourinary Cancer [ISSN 1558-7673], v. 17 (3), p. e645-e649, (Junio 2019)
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

3
checked on Sep 18, 2022

WEB OF SCIENCETM
Citations

2
checked on Sep 18, 2022

Page view(s)

52
checked on Aug 6, 2022

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.