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Title: Mediterranean alcohol-drinking pattern, low to moderate alcohol intake and risk of atrial fibrillation in the PREDIMED study
Authors: Bazal, P.
Gea, A.
Martínez-González, M. A.
Salas-Salvadó, J.
Asensio, E. M.
Muñoz-Bravo, C.
Fiol, M.
Muñoz, M. A.
Lapetra, J.
Serra-Majem, L. L. 
Pintó, X.
González, J. I.
Becerra-Tomás, N.
Fitó, M.
Ros, E.
Alonso-Gómez, A.
Ruiz-Canela, M.
UNESCO Clasification: 3206 Ciencias de la nutrición
241103 Fisiología cardiovascular
Keywords: Alcohol
Atrial Fibrillation
Red Wine
Issue Date: 2019
Project: Efecto de Una Intervención Intensiva de Pérdida de Peso Con Dieta Mediterránea Hipocalórica, Actividad Física y Tratamiento Conductual Sobre la Prevención Primaria Cardiovascular: Ensayo Predimed-Plus 
Journal: Nutrition, Metabolism and Cardiovascular Diseases 
Abstract: There is ongoing controversy about the effect of a low to moderate alcohol consumption on atrial fibrillation (AF). Our aim is to assess the association between adherence to a Mediterranean alcohol drinking pattern and AF incidence. Methods and results: A total 6527 out of the 7447 participants in the PREDIMED trial met our inclusion criteria. A validated frequency food questionnaire was used to measure alcohol consumption. Participants were classified as non-drinkers, Mediterranean alcohol drinking pattern (MADP) (10–30 g/d in men and 5–15 g/day in women, preferably red wine consumption with low spirits consumption), low-moderate drinking (<30 g/day men y and < 15 g/day women), and heavy drinking. We performed multivariable Cox regression models to estimate hazard ratios (HR) with 95% confidence intervals (95% CI) of incident AF according to alcohol drinking patterns. After a mean follow up of 4.4 years, 241 new incident AF cases were confirmed. Alcohol consumption was not associated to AF incidence among low-moderate drinkers (HR: 0.96; 95%CI: 0.67–1.37), adherents to MADP (HR: 1.15 95%CI: 0.75–1.75), or heavy drinkers (HR: 0.92; 95%CI: 0.53–1.58), compared with non-drinkers. Conclusions: In a high cardiovascular risk adult population, a Mediterranean alcohol consumption pattern (low to moderate red wine consumption) was not associated with an increased incidence of AF. Clinical trials: URL: Unique identifier: ISRCTN35739639.
ISSN: 0939-4753
DOI: 10.1016/j.numecd.2019.03.007
Source: Nutrition, Metabolism and Cardiovascular Diseases [ISSN 0939-4753], v. 29 (7), p. 676-683
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