Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/69870
Título: Distinct Patterns of Hair Graft Survival After Transplantation Into 2 Nonhealing Ulcers: Is Location Everything?
Autores/as: Alam, Majid
Cooley, Jerry
Plotczyk, Magdalena
Martínez-Martín, María Soledad 
Izeta, Ander
Paus, Ralf
Jimenez, Francisco
Clasificación UNESCO: 320106 Dermatología
Palabras clave: Stem-Cells
Follicle Neogenesis
Skin-Grafts
Regeneration
Reepithelialization, et al.
Fecha de publicación: 2019
Publicación seriada: Dermatologic Surgery 
Resumen: BACKGROUND: Studies highlighting the role of hair follicles (HFs) in wound healing have raised the challenge of bringing this knowledge to clinical applications. A successful translation is the transplantation of scalp HFs into chronic wounds to promote healing. OBJECTIVE: To characterize scar formation and hair growth in nonhealing ulcers after transplantation. PATIENTS AND METHODS: Nonhealing ulcers were treated with hair transplantation to promote wound healing. Hair follicles were harvested from the patient's scalp and inserted into the wound bed. Wound repair and hair growth were assessed clinically. Further analyses were performed in situ, using biopsies from the central and peripheral scar. RESULTS: Rapid wound closure and differences of scar quality and hair growth between the central and peripheral wound areas were observed: the periphery healed with no hair shaft survival and an almost scarless appearance, the center healed with a fibrotic scar, with some hair shaft growth. In situ analyses revealed differences in dermal remodeling and collagen formation between central and peripheral scar areas. CONCLUSION: Besides confirming the effectiveness of this therapy to promote wound healing in human skin, location-dependent disparities in scar quality and hair growth raise the intriguing question whether they are due to clinically important differences in mechanical forces and/or wound microenvironments between ulcer center and periphery.
URI: http://hdl.handle.net/10553/69870
ISSN: 1076-0512
DOI: 10.1097/DSS.0000000000001748
Fuente: Dermatologic surgery [ISSN 1076-0512], v. 45 (4), p. 557-565
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