Synthesis, characterization and antiproliferative activity of mixed ligand complexes of Cu2+ and Co2+ with lapachol

Title:	Synthesis, characterization and antiproliferative activity of mixed ligand complexes of Cu2+ and Co2+ with lapachol
Authors:	Hernández-Molina, Rita Abramov, Pavel A. González-Platas, Javier Oramas-Royo, Sandra Estévez-Braun, Ana Guerra Rodríguez, Miguel Alfonso Aranda Tavío, Haidee Magdalena Guerra, Borja Fernández-Pérez, Leandro
UNESCO Clasification:	2403 Bioquímica 2418 Radiobiologia
Keywords:	Biological Activity Cobalt Copper Lapachol X-Ray Structures
Issue Date:	2019
Project:	Desarrollo Preclínico de Nuevas Estructuras Bioactivas Moduladoras de Las Actividades Oncogénicas de Stat3/5 O de Los Receptores de Estrógenos
Journal:	Polyhedron
Abstract:	Mixed ligand complexes [Cu(phen)(Lap)2] (1) and [Co(dppeO)(Lap)2] (2) were synthesized from the reaction of lapachol (Lap) with [Cu(phen)Cl2] or [Co(dppe)Cl2] in the presence of Et3N. Complexes (1) and (2) were fully characterized by X-ray crystallography, elemental analyses, and infrared spectroscopy. Antiproliferative activities of complexes (1) and (2) against several tumor cell lines were also determined alongside those of [Cu(Lap)2(EtOH)2] (3) and [Co(Lap)2(EtOH)2] (4).
URI:	http://hdl.handle.net/10553/69849
ISSN:	0277-5387
DOI:	10.1016/j.poly.2019.03.010
Source:	Polyhedron [ISSN 0277-5387], v. 165, p. 73-78
Appears in Collections:	Artículos

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