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Title: Comparison of low-pressure oxygen plasma and chemical treatments for surface modifications of Ti6Al4V
Authors: Alemán-Domínguez, María Elena 
Ortega, Zaida 
Benítez, Antonio N. 
Romero-Pérez, Aday
Wang, Ling
Santana-Farré, Ruymán
Rodríguez-Esparragón, Francisco 
UNESCO Clasification: 3303 ingeniería y tecnología químicas
Keywords: Low-Pressure Plasma
Surface Activation
Surface Functionalization
Titanium Alloys
Issue Date: 2019
Project: "Mejora de la osteointegración de estructuras porosas de titanio mediante la optimización del diseño y modificación superficial con recubrimiento polimerico". 
Sistema completo de caracterización de la relación entre composición, estructura y fotoactividad de sólidos sintéticos con aplicaciones fotocatalíticas. 
Biomaterials and Additive Manufacturing: Osteochondral Scaffold innovation applied to osteoarthritis 
Journal: Bio-design and manufacturing 
Abstract: Different treatments were conducted over Ti6Al4V samples in order to produce a surface modification to increase cell attachment and proliferation. The surface treatments evaluated in this study were as follows: etching with sulfuric acid/hydrochloric acid, oxidizing with hydrogen peroxide and low-pressure oxygen plasma treatment. In contrast to other works found in the literature, this research conducts a comparison between different chemical and physical treatments in terms of different assays for surface characterization: X-ray diffraction, scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy, water contact angle, release of vanadium ions and cell viability tests (MTT) of human osteoblasts (hFOB 1.19). Cell morphology over the different substrates was also studied by SEM observation. It was found that plasma and peroxide treatments increase the O/Ti ratio at the titanium surface and provide an increase in cell affinity. On the other hand, acid etching provides a superhydrophilic surface which is not able to improve the cell attachment of human osteoblasts. Graphical abstract: [Figure not available: see fulltext.].
ISSN: 2096-5524
DOI: 10.1007/s42242-019-00036-9
Source: Bio-Design and Manufacturing [ISSN 2096-5524], v. 2 (2), p. 65-75, (Junio 2019)
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