Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/69828
Title: Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism
Authors: Papandreou, Christopher
Li, Jun
Liang, Liming
Bulló, Mònica
Zheng, Yan
Ruiz-Canela, Miguel
Yu, Edward
Guasch-Ferré, Marta
Razquin, Cristina
Clish, Clary
Corella, Dolores
Estruch, Ramon
Ros, Emilio
Fitó, Montserrat
Arós, Fernando
Serra Majem, Luis 
Rosique, Nuria
Martínez-González, Miguel A.
Hu, Frank B.
Salas-Salvadó, Jordi
UNESCO Clasification: 32 Ciencias médicas
Keywords: Adenosine
Allantoin
Issue Date: 2019
Journal: Scientific Reports 
Abstract: Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associations. This is a case-cohort design study within the PREDIMED study, with 251 incident T2D cases and a random sample of 694 participants (641 non-cases and 53 overlapping cases) without T2D at baseline (median follow-up: 3.8 years). Metabolites were semi-quantitatively profiled with LC-MS/MS. Cox regression analysis revealed that high plasma allantoin levels, including allantoin-to-uric acid ratio and high xanthine-to-hypoxanthine ratio were inversely and positively associated with T2D risk, respectively, independently of classical risk factors. Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. The potential mechanisms linking the aforementioned purine metabolites and T2D risk must be also further investigated.
URI: http://hdl.handle.net/10553/69828
ISSN: 2045-2322
DOI: 10.1038/s41598-019-39441-6
Source: Scientific Reports, [ISNN 2045-2322], v. 9 (1)
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