Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/69434
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dc.contributor.authorDonate González, Ricardoen_US
dc.contributor.authorMonzón, Marioen_US
dc.contributor.authorOrtega, Zaidaen_US
dc.contributor.authorWang, Lingen_US
dc.contributor.authorRibeiro, Vivianaen_US
dc.contributor.authorPestana Guillén, Jesús Daviden_US
dc.contributor.authorOliveira, Joaquim M.en_US
dc.contributor.authorReis, Rui L.en_US
dc.date.accessioned2020-01-28T11:22:23Z-
dc.date.available2020-01-28T11:22:23Z-
dc.date.issued2020en_US
dc.identifier.issn1932-7005en_US
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/69434-
dc.description.abstractIn this study, polylactic acid (PLA)‐based composite scaffolds with calcium carbonate (CaCO3) and beta‐tricalcium phosphate (β‐TCP) were obtained by 3D printing. These structures were evaluated as potential 3D structures for bone tissue regeneration. Morphological, mechanical, and biological tests were carried out in order to compare the effect of each additive (added in a concentration of 5% w/w) and the combination of both (2.5% w/w of each one), on the PLA matrix. The scaffolds manufactured had a mean pore size between 400–425 μm and a porosity value in the range of 50–60%. According to the results, both additives promoted an increase of the porosity, hydrophilicity, and surface roughness of the scaffolds, leading to a significant improvement of the metabolic activity of human osteoblastic osteosarcoma cells. The best results in terms of cell attachment after 7 days were obtained for the samples containing CaCO3 and β‐TCP particles due to the synergistic effect of both additives, which results in an increase in osteoconductivity and in a microporosity that favours cell adhesion. These scaffolds (PLA:CaCO3:β‐TCP 95:2.5:2.5) have suitable properties to be further evaluated for bone tissue engineering applications.en_US
dc.languageengen_US
dc.relationBiomaterials And Additive Manufacturing: Osteochondral Scaffold Innovation Applied To Osteoarthritisen_US
dc.relationMejora de la Biofuncionalidad de Scaffolds Polimericos Obtenidos Por Fabricacion Aditivaen_US
dc.relation.ispartofJournal of tissue engineering and regenerative medicineen_US
dc.sourceJournal of tissue engineering and regenerative medicine [ISSN 1932-7005], v. 14 (2), p. 272-383en_US
dc.subject3313 Tecnología e ingeniería mecánicasen_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherAdditive manufacturingen_US
dc.subject.otherBone regenerationen_US
dc.subject.otherCalcium carbonateen_US
dc.subject.otherMetabolic activityen_US
dc.subject.otherTissue engineeringen_US
dc.subject.otherPolylactic aciden_US
dc.subject.otherPorosityen_US
dc.subject.otherβ‐tricalcium phosphateen_US
dc.titleComparison between calcium carbonate and β-tricalcium phosphate as additives of 3D printed scaffolds with polylactic acid matrixen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/term.2990en_US
dc.identifier.scopus85075716967-
dc.identifier.isi000498600400001-
dc.contributor.authorscopusid57201736831-
dc.contributor.authorscopusid7003371153-
dc.contributor.authorscopusid36241994700-
dc.contributor.authorscopusid57207735504-
dc.contributor.authorscopusid56104780500-
dc.contributor.authorscopusid56443831400-
dc.contributor.authorscopusid57199733535-
dc.contributor.authorscopusid57208122806-
dc.identifier.eissn1932-7005-
dc.description.lastpage283en_US
dc.identifier.issue2-
dc.description.firstpage272en_US
dc.relation.volume14en_US
dc.investigacionIngeniería y Arquitecturaen_US
dc.type2Artículoen_US
dc.contributor.daisngid27864957-
dc.contributor.daisngid21248221-
dc.contributor.daisngid2273115-
dc.contributor.daisngid31983288-
dc.contributor.daisngid3440118-
dc.contributor.daisngid2003421-
dc.contributor.daisngid6851853-
dc.contributor.daisngid1183-
dc.description.numberofpages12en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Donate, R-
dc.contributor.wosstandardWOS:Monzon, M-
dc.contributor.wosstandardWOS:Ortega, Z-
dc.contributor.wosstandardWOS:Wang, L-
dc.contributor.wosstandardWOS:Ribeiro, V-
dc.contributor.wosstandardWOS:Pestana, D-
dc.contributor.wosstandardWOS:Oliveira, JM-
dc.contributor.wosstandardWOS:Reis, RL-
dc.date.coverdateFebrero 2020en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-INGen_US
dc.description.sjr0,835
dc.description.jcr3,963
dc.description.sjrqQ2
dc.description.jcrqQ2
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.project.principalinvestigatorMonzón Verona, Mario Domingo-
crisitem.project.principalinvestigatorMonzón Verona, Mario Domingo-
crisitem.author.deptGIR Fabricación integrada y avanzada-
crisitem.author.deptDepartamento de Ingeniería Mecánica-
crisitem.author.deptGIR Fabricación integrada y avanzada-
crisitem.author.deptDepartamento de Ingeniería de Procesos-
crisitem.author.orcid0000-0002-4337-5991-
crisitem.author.orcid0000-0003-2736-7905-
crisitem.author.orcid0000-0002-7112-1067-
crisitem.author.parentorgDepartamento de Ingeniería Mecánica-
crisitem.author.parentorgDepartamento de Ingeniería Mecánica-
crisitem.author.fullNameDonate González, Ricardo-
crisitem.author.fullNameMonzón Verona, Mario Domingo-
crisitem.author.fullNameOrtega Medina, Zaida Cristina-
crisitem.author.fullNamePestana Guillén, Jesús David-
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