Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/69324
Campo DC Valoridioma
dc.contributor.authorPaz Hernández, Rubénen_US
dc.contributor.authorMonzón Verona, Mario D.en_US
dc.date.accessioned2020-01-24T11:54:41Z-
dc.date.available2020-01-24T11:54:41Z-
dc.date.issued2019en_US
dc.identifier.issn2040-7939en_US
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/69324-
dc.description.abstractThe optimum scaffold for tissue engineering must guarantee the mechanical integrity in the damaged zone and ensure an appropriate stiffness to regulate the cellular function. For this to happen, scaffolds must be designed to match the stiffness of the native tissue. Moreover, the degradation rate in the case of bioresorbable materials must also be considered to fit the tissue regeneration rate. This paper presents a methodology based on design of experiments, finite element analysis, metamodels, and genetic algorithms to optimize the assignation of material in different sections of the scaffold to obtain the desired stiffness over time and comply with the constraints needed. The method applies an initial sampling focused on a modified Latin Hypercube strategy to obtain data from the simulations. These data are used in the next stages to generate the metamodels by using kriging. The predictions of the metamodels are used by the genetic algorithms to find the best estimated solutions. Different runs of the genetic algorithm drive the sampling, improving the accuracy of the surrogate models over the optimization process. Once the accuracy of the metamodels estimates is sufficient, a final genetic algorithm is applied to obtain the optimum design. This approach guarantees a low sampling effort and convergence to carry out the optimization process. The method allows the combination of discrete and continuous design variables in the optimization problem, and it can be applied both in solid and in hierarchical-based geometries.en_US
dc.languageengen_US
dc.relationMejora de la Biofuncionalidad de Scaffolds Polimericos Obtenidos Por Fabricacion Aditivaen_US
dc.relationBiomaterials and Additive Manufacturing: Osteochondral Scaffold innovation applied to osteoarthritisen_US
dc.relation.ispartofInternational Journal for Numerical Methods in Biomedical Engineeringen_US
dc.sourceInternational Journal For Numerical Methods In Biomedical Engineering [ISSN 2040-7939], v. 35 (10)en_US
dc.subject3328 Procesos tecnológicosen_US
dc.subject.otherOptimal-Designen_US
dc.subject.otherTissueen_US
dc.subject.otherMicrostructureen_US
dc.subject.otherArchitectureen_US
dc.subject.otherGeometryen_US
dc.subject.otherCellsen_US
dc.titleOptimization methodology for the material assignation in bioprinted scaffolds to achieve the desired stiffness over timeen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/cnm.3248en_US
dc.identifier.scopus85071243936-
dc.identifier.isi000482845800001-
dc.contributor.authorscopusid8590822200-
dc.contributor.authorscopusid7003371153-
dc.identifier.eissn2040-7947-
dc.identifier.issue10-
dc.relation.volume35en_US
dc.investigacionIngeniería y Arquitecturaen_US
dc.type2Artículoen_US
dc.contributor.daisngid2158374-
dc.contributor.daisngid1363424-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Paz, R-
dc.contributor.wosstandardWOS:Monzon, MD-
dc.date.coverdateOctubre 2019en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-INGen_US
dc.description.sjr0,686-
dc.description.jcr2,097-
dc.description.sjrqQ2-
dc.description.jcrqQ2-
dc.description.scieSCIE-
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.project.principalinvestigatorMonzón Verona, Mario Domingo-
crisitem.project.principalinvestigatorMonzón Verona, Mario Domingo-
crisitem.author.deptGIR Fabricación integrada y avanzada-
crisitem.author.deptDepartamento de Ingeniería Mecánica-
crisitem.author.deptGIR Fabricación integrada y avanzada-
crisitem.author.deptDepartamento de Ingeniería Mecánica-
crisitem.author.orcid0000-0003-1223-7067-
crisitem.author.orcid0000-0003-2736-7905-
crisitem.author.parentorgDepartamento de Ingeniería Mecánica-
crisitem.author.parentorgDepartamento de Ingeniería Mecánica-
crisitem.author.fullNamePaz Hernández, Rubén-
crisitem.author.fullNameMonzón Verona, Mario Domingo-
Colección:Artículos
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