Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/6511
Campo DC | Valor | idioma |
---|---|---|
dc.contributor.author | van Hall, Gerrit | - |
dc.contributor.author | Lundby, Carsten | - |
dc.contributor.author | Araoz, M. | - |
dc.contributor.author | Calbet, J. A. L. | - |
dc.contributor.author | Sander, M. | - |
dc.contributor.author | Saltin, Bengt | - |
dc.contributor.other | Calbet, Jose A | |
dc.contributor.other | van Hall, Gerrit | |
dc.date.accessioned | 2011-10-26T02:31:00Z | - |
dc.date.accessioned | 2018-03-08T13:10:57Z | - |
dc.date.available | 2011-10-26T09:12:32Z | - |
dc.date.available | 2018-03-08T13:10:57Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0022-3751 | - |
dc.identifier.uri | http://hdl.handle.net/10553/6511 | - |
dc.description.abstract | Chronic hypoxia has been proposed to induce a closer coupling in human skeletal muscle between ATP utilization and production in both lowlanders (LN) acclimatizing to high altitude and high-altitude natives (HAN), linked with an improved match between pyruvate availability and its use in mitochondrial respiration. This should result in less lactate being formed during exercise in spite of the hypoxaemia. To test this hypothesis six LN (22-31 years old) were studied during 15 min warm up followed by an incremental bicycle exercise to exhaustion at sea level, during acute hypoxia and after 2 and 8 weeks at 4100 m above sea level (El Alto, Bolivia). In addition, eight HAN (26-37 years old) were studied with a similar exercise protocol at altitude. The leg net lactate release, and the arterial and muscle lactate concentrations were elevated during the exercise in LN in acute hypoxia and remained at this higher level during the acclimatization period. HAN had similar high values; however, at the moment of exhaustion their muscle lactate, ADP and IMP content and Cr/PCr ratio were higher than in LN. In conclusion, sea-level residents in the course of acclimatization to high altitude did not exhibit a reduced capacity for the active muscle to produce lactate. Thus, the lactate paradox concept could not be demonstrated. High-altitude natives from the Andes actually exhibit a higher anaerobic energy production than lowlanders after 8 weeks of acclimatization reflected by an increased muscle lactate accumulation and enhanced adenine nucleotide breakdown. | es |
dc.language | spa | es |
dc.relation.ispartof | Journal of Physiology | es-ES |
dc.source | Journal Of Physiology-London[ISSN 0022-3751],v. 587 (5), p. 1117-1129 | es |
dc.subject | 241106 Fisiología del ejercicio | es |
dc.subject.other | Hypoxia | es |
dc.subject.other | Lactate | es |
dc.subject.other | Exercise | es |
dc.title | The lactate paradox revisited in lowlanders during acclimatization to 4100 m and in high-altitude natives | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type | Article | es |
dc.identifier.doi | 10.1113/jphysiol.2008.160846 | - |
dc.identifier.scopus | 2-s2.0-61649103127 | - |
dc.identifier.isi | 000263759800014 | |
dcterms.isPartOf | Journal Of Physiology-London | |
dcterms.source | Journal Of Physiology-London[ISSN 0022-3751],v. 587 (5), p. 1117-1129 | |
dc.identifier.absysnet | 641103 | - |
dc.identifier.crisid | 475 | - |
dc.identifier.eissn | 1469-7793 | - |
dc.description.lastpage | 1129 | |
dc.description.firstpage | 1117 | |
dc.relation.volume | 587 | |
dc.investigacion | Ciencias de la Salud | es |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | es |
dc.type2 | Artículo | es |
dc.identifier.wos | WOS:000263759800014 | - |
dc.contributor.daisngid | 209461 | |
dc.contributor.daisngid | 95120 | |
dc.contributor.daisngid | 1817813 | |
dc.contributor.daisngid | 90295 | |
dc.contributor.daisngid | 844155 | |
dc.contributor.daisngid | 13919 | |
dc.identifier.investigatorRID | H-6693-2015 | |
dc.identifier.investigatorRID | No ID | |
dc.identifier.ulpgc | Sí | es |
dc.description.jcr | 4,764 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
item.grantfulltext | open | - |
item.fulltext | Con texto completo | - |
crisitem.author.dept | GIR IUIBS: Rendimiento humano, ejercicio físico y salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Educación Física | - |
crisitem.author.orcid | 0000-0002-9215-6234 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | López Calbet, José Antonio | - |
Colección: | Artículos |
Vista resumida
Citas SCOPUSTM
37
actualizado el 17-nov-2024
Citas de WEB OF SCIENCETM
Citations
30
actualizado el 17-nov-2024
Visitas
74
actualizado el 23-may-2024
Descargas
250
actualizado el 23-may-2024
Google ScholarTM
Verifica
Altmetric
Comparte
Exporta metadatos
Este elemento está sujeto a una licencia Licencia Creative Commons