Study of the immunomodulatory and antiviral activity of bacterial Iipopolysaccharides in seabass (Dicentrarchus labrax, Linnaeus 1758)

Abstract

Diseases are the main cause of economic losses in the aquaculture sector that's why researching and improving this immunomodulation technique is fundamental. In this research work, the immunomodulatory effect of the lipopolysaccharides (LPS) of Vibrio alginolyticus was evaluated in a species of commercial interest, the seabass, through the cytokines, one kind of humoral components. Three groups of fish were evaluated, one unstimulated control, another positive stimulated with Poly I: C and another stimulated with LPS. The results showed statistically significant differences between the stimulants, where it was observed that the expression of the inflammatory (IL-1β, IL-6 and TNFα) and anti-inflammatory (IL-10) cytokines was directly related. The antiviral response (Mx) was different between the treatments and it was seen that with LPS the stimulating effect was more prolonged in time, although weaker.