Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/59997
Título: Effects of Dietary Lipid Composition and Fatty Acid Desaturase 2 Expression in Broodstock Gilthead Sea Bream on Lipid Metabolism-Related Genes and Methylation of the fads2 Gene Promoter in Their Offspring
Autores/as: Turkmen, Serhat
Perera, Erick
Zamorano, Maria J. 
Simó-Mirabet, Paula
Xu, Hanlin
Pérez-Sánchez, Jaume
Izquierdo, Marisol 
Clasificación UNESCO: 310502 Piscicultura
Palabras clave: DNA methylation
Digital droplet PCR
Modulation of lipid metabolism
Nutritional programming
Parental nutrition
Fecha de publicación: 2019
Proyectos: Consumer driven Production: Integrating Innovative Approaches for Competitive and Sustainable Performance across the Mediterranean Aquaculture Value Chain 
Publicación seriada: International Journal of Molecular Sciences 
Resumen: Polyunsaturated fatty acids (PUFA) in parental diets play a key role in regulating n-3 LC-PUFA metabolism of the offspring. However, it is not clear whether this metabolic regulation is driven by the precursors presented in the diet or by the parental ability to synthesize them. To elucidate this, broodstocks of gilthead sea bream with different blood expression levels of fads2, which encodes for the rate-limiting enzyme in the n-3 LC-PUFA synthesis pathway, were fed either a diet supplemented with alpha-linolenic acid (ALA, 18:3n-3) or a control diet. The progenies obtained from these four experimental groups were then challenged with a low LC-PUFA diet at the juvenile stage. Results showed that the offspring from parents with high fads2 expression presented higher growth and improved utilization of low n-3 LC-PUFA diets compared to the offspring from parents with low fads2 expression. Besides, an ALA-rich diet during the gametogenesis caused negative effects on the growth of the offspring. The epigenetic analysis demonstrated that methylation in the promoter of fads2 of the offspring was correlated with the parental fads2 expression levels and type of the broodstock diet.
URI: http://hdl.handle.net/10553/59997
ISSN: 1422-0067
DOI: 10.3390/ijms20246250
Fuente: International journal of molecular sciences [ISSN 1422-0067], v. 20 (24), 6250
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