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Title: Glial cells and retinal nerve fibers morphology in the optic nerves of streptozotocin-induced hyperglycemic rats
Authors: Alemán Flores, Rafael 
Mompeó Corredera, Blanca Rosa 
UNESCO Clasification: 320109 Oftalmología
240703 Morfología celular
Keywords: Hyperglycemia
Model Animal
Myelin Sheath
Optic Nerve, et al
Issue Date: 2018
Journal: Journal of Ophthalmic and Vision Research 
Abstract: Purpose: This study analyzes the structures of optic nerve elements, i.e., glial cells and nerve fibers, in an STZ-induced hyperglycemic animal model. Morphological changes in glial elements of the optic nerve in hyperglycemic and normoglycemic animals were compared. Methods: Transmission electron microscopy, histochemistry, immunohistochemistry, and morphometry were used in this study. Results: Hyperglycemia increased the numbers of inner mesaxons and axons with degenerative profiles. Furthermore, it led to both an increase in the amount of debris and in the numbers of secondary lysosomic vesicles in glial cytoplasm. Hyperglycemia also led to a decrease in glial fibrillary acidic protein expression and an increase in periodic acid-Schiff-positive deposits in the optic nerves of hyperglycemic animals. Conclusion: We conclude that the damage to the structural elements observed in our animal models contributes to the pathogenesis of optic neuropathy in the early stages of diabetes.
ISSN: 2008-2010
DOI: 10.4103/jovr.jovr_130_17
Source: Journal of Ophthalmic and Vision Research [ISSN 2008-2010], v. 13 (4), p. 433-438, (Octubre-Diciembre 2018)
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