Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/56281
Título: Glial cells and retinal nerve fibers morphology in the optic nerves of streptozotocin-induced hyperglycemic rats
Autores/as: Alemán Flores, Rafael 
Mompeó Corredera, Blanca Rosa 
Clasificación UNESCO: 320109 Oftalmología
240703 Morfología celular
Palabras clave: Hyperglycemia
Model Animal
Myelin Sheath
Neuroglia
Optic Nerve, et al.
Fecha de publicación: 2018
Publicación seriada: Journal of Ophthalmic and Vision Research 
Resumen: Purpose: This study analyzes the structures of optic nerve elements, i.e., glial cells and nerve fibers, in an STZ-induced hyperglycemic animal model. Morphological changes in glial elements of the optic nerve in hyperglycemic and normoglycemic animals were compared. Methods: Transmission electron microscopy, histochemistry, immunohistochemistry, and morphometry were used in this study. Results: Hyperglycemia increased the numbers of inner mesaxons and axons with degenerative profiles. Furthermore, it led to both an increase in the amount of debris and in the numbers of secondary lysosomic vesicles in glial cytoplasm. Hyperglycemia also led to a decrease in glial fibrillary acidic protein expression and an increase in periodic acid-Schiff-positive deposits in the optic nerves of hyperglycemic animals. Conclusion: We conclude that the damage to the structural elements observed in our animal models contributes to the pathogenesis of optic neuropathy in the early stages of diabetes.
URI: http://hdl.handle.net/10553/56281
ISSN: 2008-2010
DOI: 10.4103/jovr.jovr_130_17
Fuente: Journal of Ophthalmic and Vision Research [ISSN 2008-2010], v. 13 (4), p. 433-438, (Octubre-Diciembre 2018)
Colección:Artículos
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