Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/55129
Title: Preventing the recurrence of depression with a Mediterranean diet supplemented with extra-virgin olive oil. the PREDI-DEP trial: Study protocol
Authors: Sánchez-Villegas, A. 
Cabrera-Suárez, B.
Molero, P.
González-Pinto, A.
Chiclana-Actis, C.
Cabrera, C.
Lahortiga-Ramos, F.
Florido-Rodríguez, M.
Vega-Pérez, P.
Vega-Pérez, R.
Pla, J.
Calviño-Cabada, M. J.
Ortuño, F.
Navarro, S.
Almeida, Y.
Hernández-Fleta, J. L. 
UNESCO Clasification: 3206 Ciencias de la nutrición
Keywords: Association
Adherence
Health
Risk
Symptoms, et al
Issue Date: 2019
Project: Prevención de la Depresión Recurrente Con Dieta Mediterranea 
Journal: BMC Psychiatry 
Abstract: Background: The role of dietary patterns in the prevention of unipolar depression has been analyzed in several epidemiological studies. The primary aims of this study are to determine the effectiveness of an extra-olive oil-enriched Mediterranean diet in reducing the recurrence of depression and improving the symptoms of this condition. Methods: Multicenter, two-arm, parallel-group clinical trial. Arm 1, extra-virgin olive oil Mediterranean diet; Arm 2, control group without nutritional intervention. Dieticians are in charge of the nutritional intervention and regular contact with the participants. Contacts are made through our web platform (https://predidep.es/participantes/) or by phone. Recurrence of depression is assessed by psychiatrists and clinical psychologists through clinical evaluations (semi-structured clinical interviews: Spanish SCID-I). Depressive symptoms are assessed with the Beck Depression Inventory. Information on quality of life, level of physical activity, dietary habits, and blood, urine and stool samples are collected after the subject has agreed to participate in the study and once a year. Discussion: To the best of our knowledge, the PREDI-DEP trial is the first ongoing randomized clinical trial designed to assess the role of the Mediterranean diet in the prevention of recurrent depression. It could be a cost-effective approach to avoid recurrence and improve the quality of life of these patients.
URI: http://hdl.handle.net/10553/55129
ISSN: 1471-244X
DOI: 10.1186/s12888-019-2036-4
Source: Bmc Psychiatry [ISSN 1471-244X], v. 19, (Febrero 2019)
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