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Title: Long-term effectiveness of levodopa-carbidopa intestinal gel in 177 Spanish patients with advanced Parkinson's disease
Authors: Valldeoriola, Francesc
Grandas, Francisco
Santos-García, Diego
Regidor, Ignacio
Catalán, María José
Arbelo, José Matías 
Puente, Víctor
Mir, Pablo
Parra, Juan Carlos
UNESCO Clasification: 32 Ciencias médicas
Keywords: Dyskinesia
Levodopa–carbidopa intestinal gel
Nonmotor symptoms
‘off’ time
Parkinson's disease
Issue Date: 2016
Journal: Neurodegenerative disease management 
Abstract: Aim: To assess long-term effectiveness and tolerability of levodopa–carbidopa intestinal gel (LCIG) in Spanish patients with advanced Parkinson's disease. Patients & methods: This was an observational, multicenter, cross-sectional, retrospective study. Results: Data of 177 patients were analyzed. LCIG treatment led to a reduction in the percentage of daily ‘off’ time (16.2 vs 47.6% before LCIG), an increase in the percentage of daily ‘on’ time without disabling dyskinesia (55.6 vs 21.6%). Most patients experienced improvements in freezing of gait, tremor, dizziness, fatigue or flat mood. Adverse events related to levodopa, gastrostomy and technical issues were reported in 36.2, 42.4 and 43.5% of patients, respectively. Conclusion: This study confirms the long-term effectiveness and safety profile of LCIG in patients with advanced Parkinson's disease.
ISSN: 1758-2024
DOI: 10.2217/nmt-2016-0021
Source: Neurodegenerative disease management [ISSN 1758-2024], v. 6(4), p. 289-298
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