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Title: Enhancement of exercise performance by 48 hours, and 15-day supplementation with mangiferin and luteolin in men
Authors: Gelabert-Rebato, Miriam 
Wiebe, Julia C.
Martin-Rincon, Marcos 
Galvan-Alvarez, Victor 
Curtelin Pérez, David 
Perez-Valera, Mario 
Habib, Julian Juan
Pérez-López, Alberto
Vega, Tanausú
Morales-Alamo, David 
Calbet, Jose A.L. 
UNESCO Clasification: 241106 Fisiología del ejercicio
Keywords: Sports nutrition
Ergogenic aids
O2 extraction, et al
Issue Date: 2019
Journal: Nutrients 
Abstract: The natural polyphenols mangiferin and luteolin have free radical-scavenging properties, induce the antioxidant gene program and down-regulate the expression of superoxide-producing enzymes. However, the effects of these two polyphenols on exercise capacity remains mostly unknown. To determine whether a combination of luteolin (peanut husk extract containing 95% luteolin, PHE) and mangiferin (mango leave extract (MLE), Zynamite®) at low (PHE: 50 mg/day; and 140 mg/day of MLE containing 100 mg of mangiferin; L) and high doses (PHE: 100 mg/day; MLE: 420 mg/day; H) may enhance exercise performance, twelve physically active men performed incremental exercise to exhaustion, followed by sprint and endurance exercise after 48 h (acute effects) and 15 days of supplementation (prolonged effects) with polyphenols or placebo, following a double-blind crossover design. During sprint exercise, mangiferin + luteolin supplementation enhanced exercise performance, facilitated muscle oxygen extraction, and improved brain oxygenation, without increasing the VO2. Compared to placebo, mangiferin + luteolin increased muscle O2 extraction during post-exercise ischemia, and improved sprint performance after ischemia-reperfusion likely by increasing glycolytic energy production, as reflected by higher blood lactate concentrations after the sprints. Similar responses were elicited by the two doses tested. In conclusion, acute and prolonged supplementation with mangiferin combined with luteolin enhances performance, muscle O2 extraction, and brain oxygenation during sprint exercise, at high and low doses.
ISSN: 2072-6643
DOI: 10.3390/nu11020344
Source: Nutrients [ISSN 2072-6643], v. 11 (2), p. 344 (Febrero 2019)
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