Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/55017
Title: Seafood consumption, omega-3 fatty acids intake, and life-time prevalence of depression in the PREDIMED-plus trial
Authors: Sánchez-Villegas, Almudena 
Álvarez-Pérez, Jacqueline 
Toledo, Estefanía
Salas-Salvadó, Jordi
Ortega-Azorín, Carolina
Zomeño, Maria Dolores
Vioque, Jesús
Martínez, Jose Alfredo
Romaguera, Dora
Pérez-López, Jessica
López-Miranda, José
Estruch, Ramón
Bueno-Cavanillas, Aurora
Arós, Fernando
Tur, Josep A.
Tinahones, Francisco J.
Lecea, Oscar
Martín, Vicente
Ortega-Calvo, M.
Vázquez, Clotilde
Pintó, Xavier
Vidal, Josep
Daimiel, Lidia
Delgado-Rodríguez, Miguel
Matía, Pilar
Corella, Dolores
Díaz-López, Andrés
Babio, Nancy
Muñoz, Miguel Ángel
Fitó, Montserrat
de la Hera, Manoli García
Abete, Itziar
García-Rios, Antonio
Ros, Emilio
Ruíz-Canela, Miguel
Martínez-González, Miguel Ángel
Izquierdo, Marisol 
Serra-Majem, Lluis 
UNESCO Clasification: 3206 Ciencias de la nutrición
Keywords: Physical-Activity Questionnaire
Polyunsaturated Fatty-Acids
Fish Consumption
N-3
Metaanalysis, et al
Issue Date: 2018
Project: Efecto de la Dieta Mediterránea Hopocalórica y Promoción de la Actividad Física en Prevención Primaria Cardiovascular.Estudio Piloto Sobre Marcadores Intermedios. 
Journal: Nutrients 
Abstract: Background: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (-3 PUFA) intake, and depression prevalence. Methods: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and -3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and -3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) -3 PUFA intake and depressive symptoms. Results: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63-0.94), 0.71 (0.58-0.87), and 0.78 (0.64-0.96), respectively, and p for trend = 0.759. Moderate intake of total LC -3 PUFA (approximately 0.5-1 g/day) was significantly associated with a lower prevalence of depression. Conclusion: In our study, moderate fish and LC -3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.
URI: http://hdl.handle.net/10553/55017
ISSN: 2072-6643
DOI: 10.3390/nu10122000
Source: Nutrients [ISSN 2072-6643], v. 10 (12), (Diciembre 2018)
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