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Title: Cross-sectional associations of objectively-measured sleep characteristics with obesity and type 2 diabetes in the PREDIMED-Plus trial
Authors: Rosique-Esteban, Nuria
Papandreou, Christopher
Romaguera, Dora
Warnberg, Julia
Corella, Dolores
Martínez-González, Miguel Ángel
Díaz-López, Andrés
Estruch, Ramon
Vioque, Jesus
Arós, Fernando
Garcia-Rios, Antonio
Bueno-Cavanillas, Aurora
Vidal, Josep
Serra-Majem, Lluís 
Sibai, Abdurrahman Adlbi
Tinahones, Francisco J.
Martínez, J. Alfredo
Ordovás, José M.
Tur, Josep A.
Ellacuría, Macarena Torrego
Sanllorente, Albert
Pintó, Xavier
Buil-Cosiales, Pilar
Fernández-Carrion, Rebeca
Castañer, Olga
Bulló, Mónica
Ruiz-Canela, Miguel
Garcia-de la Hera, Manoli
Pérez-Farinós, Napoleon
Barón-López, F. Javier
Colom, Antoni
Abete, Itziar
Ros, Emilio
Salas-Salvadó, Jordi
Keywords: Abdominal Obesity
Weight Change
Duration, et al
Issue Date: 2018
Project: Efecto de la Dieta Mediterránea Hopocalórica y Promoción de la Actividad Física en Prevención Primaria Cardiovascular.Estudio Piloto Sobre Marcadores Intermedios. 
Efecto de Una Pérdida de Peso Con Dieta Mediterránea Hipocalórica y Promoción de la Actividad Física en la Prevención Primaria Cardiovascular 
Neuroprotección Por Bloqueo de la Capacidad de Transactivadora Nf-Kb y Factores Relacionados. 
Journal: Sleep 
Abstract: Study Objectives: To examine independent and combined associations of sleep duration and sleep variability with body composition, obesity and type 2 diabetes (T2D) in elders at high cardiovascular risk.Methods: Cross-sectional analysis of 1986 community-dwelling elders with overweight/obesity and metabolic syndrome from PREDIMEDPlus trial. Associations of accelerometry-derived sleep duration and sleep variability with body mass index (BMI), waist circumference (WC) and body composition were assessed fitting multivariable-adjusted linear regression models. Prevalence ratios (PR) and 95% confidence intervals (CI) for obesity and T2D were obtained using multivariable-adjusted Cox regression with constant time. "Bad sleepers" (age-specific non-recommended sleep duration plus sleep variability above the median) and "good sleepers" (age-specific recommended sleep duration plus sleep variability below the median) were characterized by combining sleep duration and sleep variability, and their associations with these outcomes were examined.Results: One hour/night increment in sleep duration was inversely associated with BMI (beta-0.38 kg/m(2) [95% CI -0.54, -0.23]), WC (beta-0.86 cm [95% CI -1.25, -0.47]), obesity (PR 0.96 [95% CI 0.93, 0.98]), T2D (PR 0.93 [95% CI 0.88, 0.98]) and other DXA-derived adiposity-related measurements (android fat and trunk fat, all p <.05). Each 1-hour increment in sleep variability was positively associated with T2D (PR 1.14 [95% CI 1.01, 1.28]). Compared with "good sleepers," "bad sleepers" were positively associated with obesity (PR 1.12 [95% CI 1.01, 1.24]) and T2D (PR 1.62 [95% CI 1.28, 2.06]).Conclusions: This study revealed cross-sectional associations of sleep duration with adiposity parameters and obesity. Sleep duration and sleep variability were associated with T2D. Considering simultaneously sleep duration and sleep variability could have additional value, particularly for T2D, as they may act synergistically.
ISSN: 1550-9109
DOI: 10.1093/sleep/zsy190
Source: Sleep [ISSN 1550-9109], v. 41 (12), (Diciembre 2018)
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