Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/54956
DC Field | Value | Language |
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dc.contributor.author | Kourtzelis, Ioannis | en_US |
dc.contributor.author | Li, Xiaofei | en_US |
dc.contributor.author | Mitroulis, Ioannis | en_US |
dc.contributor.author | Grosser, Daniel | en_US |
dc.contributor.author | Kajikawa, Tetsuhiro | en_US |
dc.contributor.author | Wang, Baomei | en_US |
dc.contributor.author | Grzybek, Michal | en_US |
dc.contributor.author | von Renesse, Janusz | en_US |
dc.contributor.author | Czogalla, Aleksander | en_US |
dc.contributor.author | Troullinaki, Maria | en_US |
dc.contributor.author | Ferreira, Anaisa | en_US |
dc.contributor.author | Doreth, Christian | en_US |
dc.contributor.author | Ruppova, Klara | en_US |
dc.contributor.author | Chen, Lan Sun | en_US |
dc.contributor.author | Hosur, Kavita | en_US |
dc.contributor.author | Lim, Jong Hyung | en_US |
dc.contributor.author | Chung, Kyoung Jin | en_US |
dc.contributor.author | Grossklaus, Sylvia | en_US |
dc.contributor.author | Tausche, Anne Kathrin | en_US |
dc.contributor.author | Joosten, Leo A.B. | en_US |
dc.contributor.author | Moutsopoulos, Niki M. | en_US |
dc.contributor.author | Wielockx, Ben | en_US |
dc.contributor.author | Castrillo, Antonio | en_US |
dc.contributor.author | Korostoff, Jonathan M. | en_US |
dc.contributor.author | Coskun, Ünal | en_US |
dc.contributor.author | Hajishengallis, George | en_US |
dc.contributor.author | Chavakis, Triantafyllos | en_US |
dc.date.accessioned | 2019-02-18T15:53:09Z | - |
dc.date.available | 2019-02-18T15:53:09Z | - |
dc.date.issued | 2019 | en_US |
dc.identifier.issn | 1529-2908 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/54956 | - |
dc.description.abstract | Resolution of inflammation is essential for tissue homeostasis and represents a promising approach to inflammatory disorders. Here we found that developmental endothelial locus-1 (DEL-1), a secreted protein that inhibits leukocyte-endothelial adhesion and inflammation initiation, also functions as a non-redundant downstream effector in inflammation clearance. In human and mouse periodontitis, waning of inflammation was correlated with DEL-1 upregulation, whereas resolution of experimental periodontitis failed in DEL-1 deficiency. This concept was mechanistically substantiated in acute monosodium-urate-crystalinduced inflammation, where the pro-resolution function of DEL-1 was attributed to effective apoptotic neutrophil clearance (efferocytosis). DEL-1-mediated efferocytosis induced liver X receptor-dependent macrophage reprogramming to a proresolving phenotype and was required for optimal production of at least certain specific pro-resolving mediators. Experiments in transgenic mice with cell-specific overexpression of DEL-1 linked its anti-leukocyte-recruitment action to endothelial cell-derived DEL-1 and its efferocytic/pro-resolving action to macrophage-derived DEL-1. Thus, the compartmentalized expression of DEL-1 facilitates distinct homeostatic functions in an appropriate context that can be harnessed therapeutically. | |
dc.language | spa | en_US |
dc.publisher | 1529-2908 | |
dc.relation.ispartof | Nature Immunology | en_US |
dc.source | Nature Immunology[ISSN 1529-2908],v. 20, p. 40-49 | en_US |
dc.subject.other | Developmental Endothelial Locus-1 | |
dc.subject.other | Gingival Crevicular Fluid | |
dc.subject.other | Resolving Lipid Mediators | |
dc.subject.other | Apoptotic Cells | |
dc.subject.other | Resolution-Phase | |
dc.subject.other | Mast-Cells | |
dc.subject.other | In-Vitro | |
dc.subject.other | Receptor | |
dc.subject.other | Periodontitis | |
dc.subject.other | Model | |
dc.title | DEL-1 promotes macrophage efferocytosis and clearance of inflammation | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/s41590-018-0249-1 | |
dc.identifier.scopus | 85056869028 | |
dc.identifier.isi | 000456273900013 | |
dc.contributor.authorscopusid | 24467890900 | |
dc.contributor.authorscopusid | 57203842799 | |
dc.contributor.authorscopusid | 25422306500 | |
dc.contributor.authorscopusid | 57204735493 | |
dc.contributor.authorscopusid | 23974603400 | |
dc.contributor.authorscopusid | 56861396100 | |
dc.contributor.authorscopusid | 8628380100 | |
dc.contributor.authorscopusid | 57189033258 | |
dc.contributor.authorscopusid | 6506016689 | |
dc.contributor.authorscopusid | 36667628400 | |
dc.contributor.authorscopusid | 57189025403 | |
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dc.contributor.authorscopusid | 55445301000 | |
dc.contributor.authorscopusid | 6603450076 | |
dc.contributor.authorscopusid | 7003315592 | |
dc.contributor.authorscopusid | 6701848455 | |
dc.contributor.authorscopusid | 7004264075 | |
dc.description.lastpage | 49 | - |
dc.description.firstpage | 40 | - |
dc.relation.volume | 20 | - |
dc.type2 | Artículo | en_US |
dc.contributor.daisngid | 1344311 | |
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dc.contributor.wosstandard | WOS:Kourtzelis, I | |
dc.contributor.wosstandard | WOS:Li, XF | |
dc.contributor.wosstandard | WOS:Mitroulis, I | |
dc.contributor.wosstandard | WOS:Grosser, D | |
dc.contributor.wosstandard | WOS:Kajikawa, T | |
dc.contributor.wosstandard | WOS:Wang, BM | |
dc.contributor.wosstandard | WOS:Grzybek, M | |
dc.contributor.wosstandard | WOS:von Renesse, J | |
dc.contributor.wosstandard | WOS:Czogalla, A | |
dc.contributor.wosstandard | WOS:Troullinaki, M | |
dc.contributor.wosstandard | WOS:Ferreira, A | |
dc.contributor.wosstandard | WOS:Doreth, C | |
dc.contributor.wosstandard | WOS:Ruppova, K | |
dc.contributor.wosstandard | WOS:Chen, LS | |
dc.contributor.wosstandard | WOS:Hosur, K | |
dc.contributor.wosstandard | WOS:Lim, JH | |
dc.contributor.wosstandard | WOS:Chung, KJ | |
dc.contributor.wosstandard | WOS:Grossklaus, S | |
dc.contributor.wosstandard | WOS:Tausche, AK | |
dc.contributor.wosstandard | WOS:Joosten, LAB | |
dc.contributor.wosstandard | WOS:Moutsopoulos, NM | |
dc.contributor.wosstandard | WOS:Wielockx, B | |
dc.contributor.wosstandard | WOS:Castrillo, A | |
dc.contributor.wosstandard | WOS:Korostoff, JM | |
dc.contributor.wosstandard | WOS:Coskun, U | |
dc.contributor.wosstandard | WOS:Hajishengallis, G | |
dc.contributor.wosstandard | WOS:Chavakis, T | |
dc.date.coverdate | Enero 2019 | |
dc.identifier.ulpgc | Sí | es |
dc.description.sjr | 9,283 | |
dc.description.jcr | 20,479 | |
dc.description.sjrq | Q1 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
item.fulltext | Sin texto completo | - |
item.grantfulltext | none | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.orcid | 0000-0002-2057-2159 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Castrillo Viguera, Antonio Jesús | - |
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