Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/54672
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dc.contributor.authorRamírez, Cristina M.
dc.contributor.authorRotllan, Noemi
dc.contributor.authorVlassov, Alexander V.
dc.contributor.authorDávalos, Alberto
dc.contributor.authorLi, Mu
dc.contributor.authorGoedeke, Leigh
dc.contributor.authorAranda, Juan F.
dc.contributor.authorCirera-Salinas, Daniel
dc.contributor.authorAraldi, Elisa
dc.contributor.authorSalerno, Alessandro
dc.contributor.authorWanschel, Amarylis
dc.contributor.authorZavadil, Jiri
dc.contributor.authorCastrillo, Antonio
dc.contributor.authorKim, Jungsu
dc.contributor.authorSuárez, Yajaira
dc.contributor.authorFernández-Hernando, Carlos
dc.date.accessioned2019-02-18T12:24:47Z-
dc.date.available2019-02-18T12:24:47Z-
dc.date.issued2013
dc.identifier.issn0009-7330
dc.identifier.urihttp://hdl.handle.net/10553/54672-
dc.description.abstractRATIONALE:: Foam cell formation because of excessive accumulation of cholesterol by macrophages is a pathological hallmark of atherosclerosis, the major cause of morbidity and mortality in Western societies. Liver X nuclear receptors (LXRs) regulate the expression of the adenosine triphosphate-binding cassette (ABC) transporters, including adenosine triphosphate-binding cassette transporter A1 (ABCA1) and adenosine triphosphate-binding cassette transporter G1 (ABCG1). ABCA1 and ABCG1 facilitate the efflux of cholesterol from macrophages and regulate high-density lipoprotein (HDL) biogenesis. Increasing evidence supports the role of microRNA (miRNAs) in regulating cholesterol metabolism through ABC transporters. OBJECTIVE:: We aimed to identify novel miRNAs that regulate cholesterol metabolism in macrophages stimulated with LXR agonists. METHODS AND RESULTS:: To map the miRNA expression signature of macrophages stimulated with LXR agonists, we performed an miRNA profiling microarray analysis in primary mouse peritoneal macrophages stimulated with LXR ligands. We report that LXR ligands increase miR-144 expression in macrophages and mouse livers. Overexpression of miR-144 reduces ABCA1 expression and attenuates cholesterol efflux to apolipoproteinA1 in macrophages. Delivery of miR-144 oligonucleotides to mice attenuates ABCA1 expression in the liver, reducing HDL levels. Conversely, silencing of miR-144 in mice increases the expression of ABCA1 and plasma HDL levels. Thus, miR-144 seems to regulate both macrophage cholesterol efflux and HDL biogenesis in the liver. CONCLUSIONS:: miR-144 regulates cholesterol metabolism via suppressing ABCA1 expression and modulation of miRNAs may represent a potential therapeutical intervention for treating dyslipidemia and atherosclerotic vascular disease. © 2013 American Heart Association, Inc.
dc.publisher0009-7330
dc.relation.ispartofCirculation research
dc.sourceCirculation Research[ISSN 0009-7330],v. 112, p. 1592-1601
dc.titleControl of cholesterol metabolism and plasma high-density lipoprotein levels by microRNA-144
dc.typeinfo:eu-repo/semantics/Article
dc.typeArticle
dc.identifier.doi10.1161/CIRCRESAHA.112.300626
dc.identifier.scopus84880031381
dc.contributor.authorscopusid8956417600
dc.contributor.authorscopusid9735359100
dc.contributor.authorscopusid6701605991
dc.contributor.authorscopusid7004810767
dc.contributor.authorscopusid56925689000
dc.contributor.authorscopusid57215063500
dc.contributor.authorscopusid42561259100
dc.contributor.authorscopusid7103385500
dc.contributor.authorscopusid42561042900
dc.contributor.authorscopusid36056016400
dc.contributor.authorscopusid7101626401
dc.contributor.authorscopusid11142276800
dc.contributor.authorscopusid7003700045
dc.contributor.authorscopusid55445301000
dc.contributor.authorscopusid8948510500
dc.contributor.authorscopusid57211512482
dc.contributor.authorscopusid6603786739
dc.contributor.authorscopusid8634881600
dc.description.lastpage1601
dc.description.firstpage1592
dc.relation.volume112
dc.type2Artículo
dc.date.coverdateJunio 2013
dc.identifier.ulpgces
dc.description.sjr6,32
dc.description.jcr11,089
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0002-2057-2159-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameCastrillo Viguera, Antonio Jesús-
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