Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/54520
Title: Trichinella: Differential expression of angiogenic factors in macrophages stimulated with antigens from encapsulated and non-encapsulated species
Authors: Shariati, F.
Pérez-Arellano, J. L. 
López-Abán, J.
Arefi, M.
Martínez-Fernández, A. R.
Muro, A.
Keywords: Endothelial Growth-Factor
Nitric-Oxide
Nurse Cell
Trichinosis
Gene
Hypoxia
Epidemiology
Mechanisms
Spiralis
Peptides
Issue Date: 2009
Publisher: 0014-4894
Journal: Experimental parasitology 
Abstract: The newborn larval stage of Trichinella spiralis enters the host striated skeletal muscle cell resulting in the formation of the nurse cell. Vascular Endothelial Growth Factor (VEGF) was detected in cells in the area immediately surrounding the nurse cells. However, no data are available on the antigens involved the, role of other angiogenic factors or the relationship of angiogenesis with Nitric Oxide (NO) production.Using macrophage cell culture we study the effect of different Trichinella L1 antigens from one encapsulated (T. spiralis) and one non-encapsulated (Trichinella pseudospiralis) on the expression of VEGF and basic Fibroblast Growth Factor (FGF2). Also, we investigate the relationship between the production of NO and angiogenic mediators. The results show that encapsulated and non-encapsulated Trichinella species are different in their capacity to stimulate the expression of VEGF and FGF2 from host macrophages. Finally, there is no relationship between angiogenic factors and NO production by T. spiralis antigen. Published by Elsevier Inc.
URI: http://hdl.handle.net/10553/54520
ISSN: 0014-4894
DOI: 10.1016/j.exppara.2009.08.016
Source: Experimental Parasitology[ISSN 0014-4894],v. 123, p. 347-353
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