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Title: Trichinella: Differing effects of antigens from encapsulated and non-encapsulated species on in vitro nitric oxide production
Authors: Andrade, M. Amparo
Siles-Lucas, Mar
López-Abán, Julio
Nogal-Ruiz, Juan José
Pérez-Arellano, José Luis 
Martínez-Fernández, Antonio R.
Muro, Antonio
Keywords: Macrophages
Issue Date: 2007
Publisher: 0304-4017
Journal: Veterinary Parasitology 
Abstract: Trichinellosis is a cosmopolitan zoonotic disease affecting a wide variety of animals, including man. Non-encapsulated and encapsulated species diverge with respect to their developmental strategies. Little is known at the molecular level about parasite-derived mediators responsible for host muscle cell transformation occurring during trichinellosis. In this context, host-parasite relationships in Trichinella-infected animals could be related to different host-immune and cell mediators, e.g. nitric oxide (NO). Here, we investigate the stimulatory/inhibitory role of L I antigens from four encapsulated (T spiralis, T britovi, T nelsoni and T nativa) and one non-encapsulated (T pseudospiralis) Trichinella species on NO production from rat macrophages in vitro. Our results demonstrate that encapsulated and non-encapsulated Trichinella species differ in their capacity to stimulate the secretion of NO from host macrophages. Biological significance of these differences should be further assessed in the available experimental models. (c) 2006 Elsevier B.V. All rights reserved.
ISSN: 0304-4017
DOI: 10.1016/j.vetpar.2006.07.026
Source: Veterinary Parasitology[ISSN 0304-4017],v. 143, p. 86-90
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