Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/53521
DC FieldValueLanguage
dc.contributor.authorQuintana, Jen_US
dc.contributor.authorFanjul, L. F.en_US
dc.contributor.authorEstevez, F.en_US
dc.contributor.authorDeniz Caceres, A.en_US
dc.contributor.authorMarrero, I.en_US
dc.contributor.authorBenitez, L.en_US
dc.contributor.authorCentol, I.en_US
dc.contributor.authorQuintana, J.en_US
dc.contributor.authorGonzalez, J.en_US
dc.contributor.authorLlanes, L.en_US
dc.contributor.authorRuiz de Galarreta, C. M.en_US
dc.contributor.otherMarrero-Arencibia, Isabel-
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherQuintana, Jose-
dc.date.accessioned2019-02-04T17:01:56Z-
dc.date.available2019-02-04T17:01:56Z-
dc.date.issued1989en_US
dc.identifier.issn0158-5231en_US
dc.identifier.urihttp://hdl.handle.net/10553/45313-
dc.description.abstractIn the present investigation the influence of androgens and progestins on the FSH modulation of progesterone biosynthesis was studied in cultured rat granulosa cells. Cells obtained from the ovaries of immature estrogen treated rats were cultured for three days in serum free medium or in medium supplemented with FSH or CPA, with or without reduced androgen DHT or the synthetic progestin R5020 alone or in combination with the anti-androgen CPA. Treatment with FSH increased pregnenolone, progesterone and 20 alpha-OHP accumulation in the culture medium 20-, 14- and 7-fold, respectively. Furthermore FSH increased the activity of the enzyme 3 beta-HSD. Concurrent treatment with DHT or R5020 augmented the FSH stimulated steroidogenesis of cultured cells. The androgen enhancement of FSH stimulated steroidogenesis of cultured granulosa cells was blocked by concomitant treatment with CPA, whereas treatment of cultures with anti-androgen did not affect the stimulatory effect of the synthetic progestin R5020.en_US
dc.languageengen_US
dc.relation.ispartofBiochemistry Internationalen_US
dc.sourceBiochemistry International [ISSN 0158-5231], v. 19 (5), p. 977-984en_US
dc.subject32 Ciencias médicasen_US
dc.subject2403 Bioquímicaen_US
dc.subject.otherAndrogen receptoren_US
dc.subject.otherProgestineen_US
dc.subject.otherProgesteroneen_US
dc.titleThe androgen receptor does not mediate progestin regulation of progesterone biosynthesis in cultured rat granulosa cellsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.scopus0024432093-
dc.identifier.isiA1989CB14300005-
dcterms.isPartOfBiochemistry International-
dcterms.sourceBiochemistry International[ISSN 0158-5231],v. 19 (5), p. 977-984-
dc.contributor.authorscopusid7004158812-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid6504219082-
dc.contributor.authorscopusid35936487800-
dc.contributor.authorscopusid7004409333-
dc.contributor.authorscopusid6505759813-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid57198495832-
dc.contributor.authorscopusid7007111159-
dc.contributor.authorscopusid7003806034-
dc.description.lastpage984en_US
dc.identifier.issue5-
dc.description.firstpage977en_US
dc.relation.volume19en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:A1989CB14300005-
dc.contributor.daisngid1127140-
dc.contributor.daisngid384944-
dc.contributor.daisngid6415762-
dc.contributor.daisngid3844163-
dc.contributor.daisngid555851-
dc.contributor.daisngid8461416-
dc.contributor.daisngid128315-
dc.contributor.daisngid19597998-
dc.contributor.daisngid161507-
dc.contributor.daisngid1664323-
dc.identifier.investigatorRIDQ-9437-2016-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDK-5709-2014-
dc.description.numberofpages8en_US
dc.utils.revisionen_US
dc.date.coverdateNoviembre 1989en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0009-0000-1982-055X-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.orcid0000-0003-3732-9929-
crisitem.author.orcid0000-0003-3732-9929-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameFanjul Rodríguez, Luisa Fernanda-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
crisitem.author.fullNameDéniz Cáceres,Antonio-
crisitem.author.fullNameMarrero Arencibia, María Isabel-
crisitem.author.fullNameMarrero Arencibia, María Isabel-
crisitem.author.fullNameQuintana Aguiar, José Martín-
Appears in Collections:Artículos
Show simple item record

SCOPUSTM   
Citations

2
checked on Sep 29, 2024

WEB OF SCIENCETM
Citations

2
checked on Feb 25, 2024

Page view(s)

40
checked on Sep 2, 2023

Google ScholarTM

Check


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.