Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/53516
Title: Eupatorin-Induced Cell Death in Human Leukemia Cells Is Dependent on Caspases and Activates the Mitogen-Activated Protein Kinase Pathway
Authors: Estevez, Sara 
Teresa Marrero, Maria
Quintana, Jose 
Estevez, Francisco 
Keywords: Mapk Pathway
Apoptosis
Cancer
Flavonoids
Constituents, et al
Issue Date: 2014
Publisher: 1932-6203
Journal: PLoS ONE 
Abstract: Eupatorin is a naturally occurring flavone that inhibits cell proliferation in human tumor cells. Here we demonstrate that eupatorin arrests cells at the G(2)-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage in human leukemia cells. This flavonoid induced the phosphorylation of members of the mitogen-activated protein kinases and cell death was attenuated by inhibition of c-jun N-terminal kinases/stress activated protein kinases. Eupatorin-induced cell death is mediated by both the extrinsic and the intrinsic apoptotic pathways and through a mechanism dependent on reactive oxygen species generation.
URI: http://hdl.handle.net/10553/53516
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0112536
Source: Plos One[ISSN 1932-6203],v. 9 (11)
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