|Title:||Erythropoietin does not reduce plasma lactate, H+, and K+ during intense exercise||Authors:||Nordsborg, N. B.
Calbet, J. A. L.
|UNESCO Clasification:||241106 Fisiología del ejercicio||Keywords:||Recombinant-Human-Erythropoietin
Metabolism, et al
|Issue Date:||2015||Journal:||Scandinavian Journal of Medicine and Science in Sports||Abstract:||It is investigated if recombinant human erythropoietin (rHuEPO) treatment for 15 weeks (n=8) reduces extracellular accumulation of metabolic stress markers such as lactate, H+, and K+ during incremental exhaustive exercise. After rHuEPO treatment, normalization of blood volume and composition by hemodilution preceded an additional incremental test. Group averages were calculated for an exercise intensity approximate to 80% of pre-rHuEPO peak power output. After rHuEPO treatment, leg lactate release to the plasma compartment was similar to before (4.3 +/- 1.6 vs 3.9 +/- 2.5mmol/min) and remained similar after hemodilution. Venous lactate concentration was higher (P<0.05) after rHuEPO treatment (7.1 +/- 1.6 vs 5.2 +/- 2.1mM). Leg H+ release to the plasma compartment after rHuEPO was similar to before (19.6 +/- 5.4 vs 17.6 +/- 6.0mmol/min) and remained similar after hemodilution. Nevertheless, venous pH was lower (P<0.05) after rHuEPO treatment (7.18 +/- 0.04 vs 7.22 +/- 0.05). Leg K+ release to the plasma compartment after rHuEPO treatment was similar to before (0.8 +/- 0.5 vs 0.7 +/- 0.7mmol/min) and remained similar after hemodilution. Additionally, venous K+ concentrations were similar after vs before rHuEPO (5.3 +/- 0.3 vs 5.1 +/- 0.4mM). In conclusion, rHuEPO does not reduce plasma accumulation of lactate, H+, and K+ at work rates corresponding to approximate to 80% of peak power output.||URI:||http://hdl.handle.net/10553/53381||ISSN:||0905-7188||DOI:||10.1111/sms.12374||Source:||Scandinavian Journal of Medicine and Science in Sports [ISSN 0905-7188], v. 25 (6), p. e566-e575, (Diciembre 2015)|
|Appears in Collections:||Artículos|
checked on Apr 11, 2021
WEB OF SCIENCETM
checked on Apr 4, 2021
checked on Apr 10, 2021
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.