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Title: Anti-Albuminuric Effects of the Angiotensin AT1 Receptor Blocker Telmisartan in Hypertensive Patients
Authors: Rodriguez-Perez, Jose C. 
Garcia-Bello, Miguel A.
Anabitarte-Prieto, Aranzazu
Companioni, Osmel
Novoa-Mogollon, Francisco J.
Suarez-Ortega, Saturnino 
Plaza-Toledano, Celia
Rodriguez-Esparragon, Francisco 
Keywords: Randomized Controlled-Trial
Overt Nephropathy
Prevention, et al
Issue Date: 2011
Publisher: 1064-1963
Journal: Clinical and Experimental Hypertension 
Abstract: We evaluated the anti-hypertensive and anti-albuminuric effect of the angiotensin receptor blocker telmisartan alone and in combination with torasemide and amlodipine. Patients were hypertensive, both diabetics and non-diabetics with persistent microalbuminuria. Our primary endpoint was a change in microalbuminuria levels, while the secondary endpoints were changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), serum creatinine levels, and glomerular filtration rate. After the 16-week treatment period, the patients significantly reduced microalbuminuria levels (76.4 +/- 52.4 mu g/min; p < 0.001), SBP (16.4 +/- 8.7 mmHg; p < 0.001) and DBP (17.7 +/- 5.9 mmHg; p < 0.001). Both diabetics and non-diabetics showed an identical pattern of significance with respect to the whole population. Systolic blood pressure, DBP, and microalbuminuria were significantly reduced as a consequence of therapy, both in diabetics and non-diabetics.
ISSN: 1064-1963
DOI: 10.3109/10641963.2011.561900
Source: Clinical And Experimental Hypertension[ISSN 1064-1963],v. 33 (8), p. 506-510
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