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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/52981
DC FieldValueLanguage
dc.contributor.authorBuset Rios, N.
dc.contributor.authorRodriguez Esparragon, F.
dc.contributor.authorFernandez-Andrade Rodriguez, C.
dc.contributor.authorRodriguez Perez, J. C.
dc.contributor.otherRodriguez-Esparragon, Francisco
dc.contributor.otherRodriguez-Perez, J.C.
dc.date.accessioned2019-02-04T14:35:53Z-
dc.date.available2019-02-04T14:35:53Z-
dc.date.issued2011
dc.identifier.issn0211-6995
dc.identifier.urihttp://hdl.handle.net/10553/52981-
dc.description.abstractThe combination of renin-angiotensin system blockers with calcium channel blockers appears to be one of the most effective options for treating hypertension and diabetes. Nevertheless, not all calcium blockers behave in the same manner. Manidipine, unlike other third-generation dihydropyridine derived drugs, blocks T-type calcium channels present in the efferent glomerular arterioles, reducing intraglomerular pressure and microalbuminuria. In addition, T-type channels are related to proliferation, inflammation, fibrosis, vasoconstriction and activation of the renin-angiotensin system. The inhibition of these factors could explain the non-haemodynamic effects of manidipine as compared to other blockers.
dc.publisher0211-6995
dc.relation.ispartofNefrologia
dc.sourceNefrologia[ISSN 0211-6995],v. 31 (3), p. 268-274
dc.subject.otherCalcium-Channel-Blockers
dc.subject.otherRandomized Controlled-Trial
dc.subject.otherPpar-Gamma Activation
dc.subject.otherEndothelial-Cells
dc.subject.otherBlood-Pressure
dc.subject.otherOlmesartan/Hydrochlorothiazide Combination
dc.subject.otherPathophysiological Significance
dc.subject.otherHypertensive Patients
dc.subject.otherCa2+ Channels
dc.subject.otherIon Channels
dc.titleVascular and metabolic properties of manidipine
dc.typeinfo:eu-repo/semantics/Article
dc.typeArticle
dc.identifier.doi10.3265/Nefrologia.pre2010.Nov.10643
dc.identifier.scopus79958244297
dc.identifier.isi000291234800006
dcterms.isPartOfNefrologia
dcterms.sourceNefrologia[ISSN 0211-6995],v. 31 (3), p. 268-274
dc.contributor.authorscopusid53464098000
dc.contributor.authorscopusid6504727864
dc.contributor.authorscopusid57199444265
dc.contributor.authorscopusid57212029793
dc.description.lastpage274
dc.identifier.issue3
dc.description.firstpage268
dc.relation.volume31
dc.type2Artículo
dc.identifier.wosWOS:000291234800006
dc.contributor.daisngid3498770
dc.contributor.daisngid1305938
dc.contributor.daisngid6272469
dc.contributor.daisngid20529678
dc.contributor.daisngid245684
dc.identifier.investigatorRIDD-2810-2013
dc.identifier.investigatorRIDC-1247-2010
dc.contributor.wosstandardWOS:Rios, NB
dc.contributor.wosstandardWOS:Esparragon, FR
dc.contributor.wosstandardWOS:Rodriguez, CFA
dc.contributor.wosstandardWOS:Perez, JCR
dc.date.coverdateJunio 2011
dc.identifier.ulpgcSíes
dc.description.sjr0,247
dc.description.jcr1,0
dc.description.sjrqQ3
dc.description.jcrqQ4
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUSA-ONEHEALTH 5: Reproducción Animal, Oncología y Anestesiología Comparadas-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptGIR IUIBS: Patología y Tecnología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0003-1663-3673-
crisitem.author.orcid0000-0003-0023-1063-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez Esparragón,Francisco Javier-
crisitem.author.fullNameRodríguez Pérez,José Carlos-
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