Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/52625
Title: Serum collagen type II cleavage epitope and serum hyaluronic acid as biomarkers for treatment monitoring of dogs with hip osteoarthritis
Authors: Vilar, Jos M. 
Rubio, Mónica
Spinella, Giuseppe
Cuervo, Belén
Sopena, Joaquín
Cugat, Ramón
Garcia-Balletbó, Montserrat
Dominguez, Juan Manuel
Granados, Maria
Tvarijonaviciute, Asta
Ceron, José J.
Carrillo, José M.
UNESCO Clasification: 3109 Ciencias veterinarias
Keywords: Mesenchymal Stem-Cells
Force Platform Analysis
Synovial-Fluid
Intraarticular Injection
Keratan Sulfate, et al
Issue Date: 2016
Project: Ministerio de Sanidad, politica e Igualdad of Spain (grant N° EC11-0046)
Journal: PLoS ONE 
Abstract: The aim of this study was to evaluate the use of serum type II collagen cleavage epitope and serum hyaluronic acid as biomarkers for treatment monitoring in osteoarthritic dogs. For this purpose, a treatment model based on mesenchymal stem cells derived from adipose tissue combined with plasma rich in growth factors was used. This clinical study included 10 dogs with hip osteoarthritis. Both analytes were measured in serum at baseline, just before applying the treatment, and 1, 3, and 6 months after treatment. These results were compared with those obtained from force plate analysis using the same animals during the same study period. Levels of type II collagen cleavage epitope decreased and those of hyaluronic acid increased with clinical improvement objectively verified via force plate analysis, suggesting these two biomarkers could be effective as indicators of clinical development of joint disease in dogs.
URI: http://hdl.handle.net/10553/52625
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0149472
Source: PLoS ONE [EISSN 1932-6203], v. 11(2), e0149472
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