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Title: Dietary total antioxidant capacity and mortality in the PREDIMED study
Authors: Henríquez Sánchez, Patricia 
Sánchez Villegas, Almudena 
Ruano Rodriguez, Cristina 
Gea, Alfredo
Lamuela-Raventós, R.M.
Estruch, Ramon
Salas-Salvadó, Jordi
Covas, M.I.
Corella, Dolores
Schröder, H.
Gutiérrez-Bedmar, Mario
Santos-Lozano, J. M.
Pintó, Xavier
Arós, Fernando
Fiol, Miquel
Tresserra-Rimbau, A.
Ros, Emilio
Martínez-González, Miguel Ángel
Serra-Majem, L. 
UNESCO Clasification: 3206 Ciencias de la nutrición
Keywords: Antioxidant intake
Dietary antioxidant capacity
Issue Date: 2016
Project: Red Alimentación Saludable en la Prevención Primaria de Enfermedades Crónicas: la Red Predimed. (Retics 2006) 
Journal: European Journal of Nutrition 
Abstract: Purpose: The aim of the present study was to assess the association between the dietary total antioxidant capacity, the dietary intake of different antioxidants and mortality in a Mediterranean population at high cardiovascular disease risk. Methods: A total of 7,447 subjects from the PREDIMED study (multicenter, parallel group, randomized controlled clinical trial), were analyzed treating data as an observational cohort. Different antioxidant vitamin intake and total dietary antioxidant capacity were calculated from a validated 137-item food frequency questionnaire at baseline and updated yearly. Deaths were ascertained through contact with families and general practitioners, review of medical records and consultation of the National Death Index. Cox regression models were fitted to assess the relationship between dietary total antioxidant capacity and mortality. Dietary total antioxidant capacity was estimated using ferric-reducing antioxidant power assays. Results: A total of 319 deaths were recorded after a median follow-up of 4.3 years. Subjects belonging to the upper quintile of antioxidant capacity were younger, ex-smokers, with high educational level, and more active and had higher alcohol intake. Multivariable-adjusted models revealed no statistically significant difference between total dietary antioxidant capacity and mortality (Q5 vs. Q1 ref HR 0.85; 95 % CI 0.60–1.20) neither for the intake of all the vitamins studied. Conclusions: No statistically significant association was found between antioxidant capacity and total mortality in elderly subjects at high cardiovascular risk.
ISSN: 1436-6207
DOI: 10.1007/s00394-015-0840-2
Source: European Journal of Nutrition [ISSN 1436-6207], v. 55 (1), p. 227-236
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