Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/52595
Title: Collision tumour of squamous cell carcinoma and malignant melanoma in the oral cavity of a dog
Authors: Rodríguez, F. 
Castro, Pedro L. 
Ramírez, G. A.
UNESCO Clasification: 3109 Ciencias veterinarias
Keywords: Dog
Melanoma
Oral mucosa
Squamous cell carcinoma
Issue Date: 2016
Journal: Journal of Comparative Pathology 
Abstract: A 7-year-old, male cocker spaniel was presented with a gingival proliferative lesion in the rostral maxilla and enlargement of the regional lymph node. Morphological and immunohistochemical analysis revealed a collision tumour composed of two malignant populations, epithelial and melanocytic, with metastasis of the neoplastic melanocytes to the regional lymph node. The epithelial component consisted of trabeculae and islands of well-differentiated squamous epithelium immunoreactive to cytokeratins. The melanocytic component had a varying degree of pigmentation of polygonal and spindle-shaped cells, growing in nests or densely packed aggregates and immunolabelled with S100, melanoma-associated antigen (melan A), neuron-specific enolase and vimentin antibodies. Protein markers involved in tumorigenesis or cell proliferation (i.e. COX-2, p53, c-kit and Ki67), were overexpressed by the neoplastic cells. To the authors' knowledge, this is the first description of an oral collision tumour involving malignant melanoma and squamous cell carcinoma in the dog.
URI: http://hdl.handle.net/10553/52595
ISSN: 0021-9975
DOI: 10.1016/j.jcpa.2016.03.004
Source: Journal of Comparative Pathology[ISSN 0021-9975],v. 154, p. 314-318
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

5
checked on Apr 11, 2021

WEB OF SCIENCETM
Citations

5
checked on Apr 11, 2021

Page view(s)

13
checked on Apr 11, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.