Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/52530
Title: Plasma acylcarnitines and risk of cardiovascular disease: Effect of Mediterranean diet interventions
Authors: Guasch-Ferré, Marta
Zheng, Yan
Ruiz-Canela, Miguel
Hruby, Adela
Martínez-González, Miguel A.
Clish, Clary B.
Corella, Dolores
Estruch, Ramon 
Ros, Emilio 
Fitó, Montserrat
Dennis, Courtney
Morales-Gil, Isabel M.
Arós, Fernando
Fiol, Miquel
Lapetra, José
Serra-Majem, Lluís 
Hu, Frank B.
Salas-Salvadó, Jordi
UNESCO Clasification: 3206 Ciencias de la nutrición
Keywords: Acylcarnitines
Cardiovascular disease
Mediterranean diet
Metabolomics
PREDIMED
Issue Date: 2016
Journal: The American journal of clinical nutrition 
Abstract: Background: Previous studies have suggested that metabolite profiles of elevated acylcarnitines were associated with increased risk of cardiovascular disease (CVD) in populations with established coronary disease. However, to our knowledge, this association has not been evaluated in the context of primary cardiovascular prevention. Objectives: We evaluated the association between 28 plasma acylcarnitine species and risk of incident CVD and the potential modifying effect of Mediterranean diet (MedDiet) interventions. Design: We measured plasma acylcarnitines with the use of high throughput liquid chromatography-tandem mass spectrometry at baseline and after 1 y of follow-up, both individually and classified into short-, medium-, or long-chain scores, in a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED) study, which is a randomized Mediterranean dietary intervention for primary cardiovascular prevention. A randomly selected sub cohort (n = 751) and all available incident CVD cases (n = 229) after 4.8 y of follow-up were included in the current study. Results: After adjustment for age, sex, body mass index, and other CVD risk factors, participants in the highest quartile of baseline short- and medium-chain acylcarnitines had a higher risk of CVD than did participants in the lowest quartile [HRs: 1.80 (95% CI: 1.11, 2.91; P-trend 0.01) and 1.55 (95% CI: 1.01, 2.48; P-trend = 0.04), respectively]. Increased short-chain acylcarnitines after 1 y were associated with higher risks of total CVD and stroke. Participants with higher baseline concentrations of short-, medium-, and long-chain acylcarnitines who were randomly assigned to the control group had a higher risk of CVD than did subjects with lower concentrations of acylcarnitines who were assigned to the MedDiet group. Conclusions: Our data support the conclusion that metabolite profiles characterized by elevated concentrations of acylcarnitines are independently associated with risks of total CVD and stroke alone in participants at high risk of CVD. MedDiet interventions may mitigate the adverse associations shown between higher concentrations of acylcarnitines and CVD.
URI: http://hdl.handle.net/10553/52530
ISSN: 0002-9165
DOI: 10.3945/ajcn.116.130492
Source: American Journal of Clinical Nutrition [ISSN 0002-9165], v. 103 (6), p. 1408-1416
Appears in Collections:Artículos
Show full item record

SCOPUSTM   
Citations

63
checked on May 9, 2021

WEB OF SCIENCETM
Citations

54
checked on Feb 21, 2021

Page view(s)

5
checked on May 10, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.