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Title: Plasma acylcarnitines and risk of cardiovascular disease: Effect of Mediterranean diet interventions
Authors: Guasch-Ferré, Marta
Zheng, Yan
Ruiz-Canela, Miguel
Hruby, Adela
Martínez-González, Miguel A.
Clish, Clary B.
Corella, Dolores
Estruch, Ramon
Ros, Emilio
Fitó, Montserrat
Dennis, Courtney
Morales-Gil, Isabel M.
Arós, Fernando
Fiol, Miquel
Lapetra, José
Serra Majem, Luis 
Hu, Frank B.
Salas-Salvadó, Jordi
UNESCO Clasification: 3206 Ciencias de la nutrición
Keywords: Acylcarnitines
Cardiovascular disease
Mediterranean diet
Issue Date: 2016
Journal: The American journal of clinical nutrition 
Abstract: Background: Previous studies have suggested that metabolite profiles of elevated acylcarnitines were associated with increased risk of cardiovascular disease (CVD) in populations with established coronary disease. However, to our knowledge, this association has not been evaluated in the context of primary cardiovascular prevention. Objectives: We evaluated the association between 28 plasma acylcarnitine species and risk of incident CVD and the potential modifying effect of Mediterranean diet (MedDiet) interventions. Design: We measured plasma acylcarnitines with the use of high throughput liquid chromatography-tandem mass spectrometry at baseline and after 1 y of follow-up, both individually and classified into short-, medium-, or long-chain scores, in a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED) study, which is a randomized Mediterranean dietary intervention for primary cardiovascular prevention. A randomly selected sub cohort (n = 751) and all available incident CVD cases (n = 229) after 4.8 y of follow-up were included in the current study. Results: After adjustment for age, sex, body mass index, and other CVD risk factors, participants in the highest quartile of baseline short- and medium-chain acylcarnitines had a higher risk of CVD than did participants in the lowest quartile [HRs: 1.80 (95% CI: 1.11, 2.91; P-trend 0.01) and 1.55 (95% CI: 1.01, 2.48; P-trend = 0.04), respectively]. Increased short-chain acylcarnitines after 1 y were associated with higher risks of total CVD and stroke. Participants with higher baseline concentrations of short-, medium-, and long-chain acylcarnitines who were randomly assigned to the control group had a higher risk of CVD than did subjects with lower concentrations of acylcarnitines who were assigned to the MedDiet group. Conclusions: Our data support the conclusion that metabolite profiles characterized by elevated concentrations of acylcarnitines are independently associated with risks of total CVD and stroke alone in participants at high risk of CVD. MedDiet interventions may mitigate the adverse associations shown between higher concentrations of acylcarnitines and CVD.
ISSN: 0002-9165
DOI: 10.3945/ajcn.116.130492
Source: American Journal of Clinical Nutrition [ISSN 0002-9165], v. 103 (6), p. 1408-1416
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