Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/52333
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dc.contributor.authorSanchez De Abajo, A.en_US
dc.contributor.authorDe La Hoya, M.en_US
dc.contributor.authorVan Puijenbroek, M.en_US
dc.contributor.authorGodino, J.en_US
dc.contributor.authorDíaz-Rubio, E.en_US
dc.contributor.authorMorreau, H.en_US
dc.contributor.authorCaldes, T.en_US
dc.date.accessioned2018-11-25T19:25:40Z-
dc.date.available2018-11-25T19:25:40Z-
dc.date.issued2006en_US
dc.identifier.issn0950-9232en_US
dc.identifier.urihttp://hdl.handle.net/10553/52333-
dc.description.abstracthMLH1 and hMSH2 can be considered tumor suppressor genes, as both alleles must be inactivated in order to lose the mismatch repair (MMR) function. In this regard, it has been proposed that LOH at MMR loci is a common Knudson's second-hit mechanism in HNPCC patients. However, experimental evidence supporting this view is scarcely found in the literature. We have performed a comprehensive analysis of LOH in 45 HNPCC tumors carrying a germline alteration in MMR loci. Overall, we have detected LOH at MMR loci in 56% of the cases. However, up to 40% of the LOH events targeted the mutant allele, arguing against a second-hit role in these tumors. Interestingly, the age at diagnosis was significantly older in these patients. To explain this and previous data, we propose a dual role for LOH at MMR loci in HNPCC.en_US
dc.languageengen_US
dc.relation.ispartofOncogeneen_US
dc.sourceOncogene[ISSN 0950-9232],v. 25, p. 2124-2130 (Marzo 2006)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320713 Oncologíaen_US
dc.subject.otherLOHen_US
dc.subject.otherHNPCCen_US
dc.subject.otherMMRen_US
dc.titleDual role of LOH at MMR loci in hereditary non-polyposis colorectal cancer?en_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/sj.onc.1209233en_US
dc.identifier.scopus33645520703-
dc.contributor.authorscopusid8503270400-
dc.contributor.authorscopusid57204609178-
dc.contributor.authorscopusid6602648059-
dc.contributor.authorscopusid57204082039-
dc.contributor.authorscopusid6701333643-
dc.contributor.authorscopusid7004153007-
dc.contributor.authorscopusid7004899792-
dc.description.lastpage2130en_US
dc.description.firstpage2124en_US
dc.relation.volume25en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages7en_US
dc.utils.revisionen_US
dc.date.coverdateMarzo 2006en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr6,582-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Diabetes y endocrinología aplicada-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSanchez De Abajo,Ana-
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