Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/52333
Campo DC | Valor | idioma |
---|---|---|
dc.contributor.author | Sanchez De Abajo, A. | en_US |
dc.contributor.author | De La Hoya, M. | en_US |
dc.contributor.author | Van Puijenbroek, M. | en_US |
dc.contributor.author | Godino, J. | en_US |
dc.contributor.author | Díaz-Rubio, E. | en_US |
dc.contributor.author | Morreau, H. | en_US |
dc.contributor.author | Caldes, T. | en_US |
dc.date.accessioned | 2018-11-25T19:25:40Z | - |
dc.date.available | 2018-11-25T19:25:40Z | - |
dc.date.issued | 2006 | en_US |
dc.identifier.issn | 0950-9232 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/52333 | - |
dc.description.abstract | hMLH1 and hMSH2 can be considered tumor suppressor genes, as both alleles must be inactivated in order to lose the mismatch repair (MMR) function. In this regard, it has been proposed that LOH at MMR loci is a common Knudson's second-hit mechanism in HNPCC patients. However, experimental evidence supporting this view is scarcely found in the literature. We have performed a comprehensive analysis of LOH in 45 HNPCC tumors carrying a germline alteration in MMR loci. Overall, we have detected LOH at MMR loci in 56% of the cases. However, up to 40% of the LOH events targeted the mutant allele, arguing against a second-hit role in these tumors. Interestingly, the age at diagnosis was significantly older in these patients. To explain this and previous data, we propose a dual role for LOH at MMR loci in HNPCC. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Oncogene | en_US |
dc.source | Oncogene[ISSN 0950-9232],v. 25, p. 2124-2130 (Marzo 2006) | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.subject | 320713 Oncología | en_US |
dc.subject.other | LOH | en_US |
dc.subject.other | HNPCC | en_US |
dc.subject.other | MMR | en_US |
dc.title | Dual role of LOH at MMR loci in hereditary non-polyposis colorectal cancer? | en_US |
dc.type | info:eu-repo/semantics/article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/sj.onc.1209233 | en_US |
dc.identifier.scopus | 33645520703 | - |
dc.contributor.authorscopusid | 8503270400 | - |
dc.contributor.authorscopusid | 57204609178 | - |
dc.contributor.authorscopusid | 6602648059 | - |
dc.contributor.authorscopusid | 57204082039 | - |
dc.contributor.authorscopusid | 6701333643 | - |
dc.contributor.authorscopusid | 7004153007 | - |
dc.contributor.authorscopusid | 7004899792 | - |
dc.description.lastpage | 2130 | en_US |
dc.description.firstpage | 2124 | en_US |
dc.relation.volume | 25 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.description.numberofpages | 7 | en_US |
dc.utils.revision | Sí | en_US |
dc.date.coverdate | Marzo 2006 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.jcr | 6,582 | - |
dc.description.jcrq | Q1 | - |
dc.description.scie | SCIE | - |
item.grantfulltext | none | - |
item.fulltext | Sin texto completo | - |
crisitem.author.dept | GIR IUIBS: Diabetes y endocrinología aplicada | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Sanchez De Abajo,Ana | - |
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