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Title: Apo(B)-dependent dyslipidemic phenotypes in type 1 diabetic patients
Authors: Wägner, Ana Marı́a 
Ordóñez-Llanos, Jordi
Hernández, Marta
Luis Sánchez-Quesada, Jose
Blanco-Vaca, Francisco
Rigla, Mercedes
de Leiva, Alberto
Pérez, Antonio
UNESCO Clasification: 32 Ciencias médicas
3205 Medicina interna
Keywords: Apolipoprotein (B)
Insulin-dependent diabetes mellitus
Diabetic dyslipidemia
Issue Date: 2001
Journal: European Journal of Internal Medicine 
Abstract: Background: The prevalence of apo(B)-dependent dyslipidemic phenotypes, which are associated with cardiovascular disease, is increased in normocholesterolemic type 2 diabetic patients. Our aim was to determine the impact of including apo(B) in the evaluation of normocholesterolemic type 1 diabetic patients. Methods: A total of 123 type 1 diabetic patients (47% male, age 36.6±12.5 years) were included. The apo(B) cut-off point (1.14 g/l) was obtained from a group of 53 normolipidemic control subjects of similar age and gender distribution; for low density lipoprotein cholesterol (LDLc), triglycerides, and high density lipoprotein cholesterol (HDLc), we used the cut-off points recommended by the National Cholesterol Education Program. LDLc was determined by ultracentrifugation or Friedewald’s equation, depending on triglyceride concentrations, and apo(B) by immunoturbidimetry. Results: A total of 113 (92%) type 1 diabetic patients were normocholesterolemic, and 13% of these were dyslipidemic. The frequency of hyperapo(B) was similar in normocholesterolemic patients and controls (6.2 vs. 9.4%, respectively). Diabetic patients with hyperapo(B) had poorer glycemic control, higher total cholesterol, triglycerides, and LDLc, and a lower HDLc and LDLc/apo(B) ratio. Conclusions: Unlike type 2 diabetes, type 1 diabetes is not associated with an increased prevalence of hyperapo(B)-dependent dyslipidemic phenotypes. Thus, only in patients with poor glycemic control who display other components of diabetic dyslipidemia, typical for type 2 diabetes, does determining apo(B) concentrations provide additional information in type 1 diabetes.
ISSN: 0953-6205
DOI: 10.1016/S0953-6205(01)00178-9
Source: European Journal of Internal Medicine[ISSN 0953-6205],v. 12(6), p. 496-502 (Diciembre 2001)
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