Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/52033
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dc.contributor.authorWägner, Ana Maríaen_US
dc.contributor.authorZapico, Edgaren_US
dc.contributor.authorBonet, Rosaen_US
dc.contributor.authorPérez, Antonioen_US
dc.contributor.authorOrdóñez-Llanos, Jordien_US
dc.date.accessioned2018-11-25T16:52:44Z-
dc.date.available2018-11-25T16:52:44Z-
dc.date.issued2003en_US
dc.identifier.issn0009-9120en_US
dc.identifier.urihttp://hdl.handle.net/10553/52033-
dc.description.abstractObjective To assess the accuracy of the direct method LDL-c Plus, in type 2 diabetic patients. Methods LDL-c Plus was measured in 64 consecutive samples of type 2 diabetic patients and compared with betaquantification (BQ), Friedewald’s and an alternative formula. LDL-c Plus was also measured in the VLDL (d<1.006 Kg/L) fraction of these samples and in total serum and the VLDL fraction of a phenotype III patient, before and after diluting it with saline or VLDL from normolipidemic subjects. Results LDL-c Plus showed a significant, constant bias (-8.5 ± 5.6%) against BQ which correlated with VLDL-cholesterol/total triglyceride ratio (r = 0.760, p < 0.0005); bias decreased to zero when the ratio increased. In the VLDL fraction of the diabetic patients and the phenotype III patient LDL-c Plus measured 20.7 ± 11.6% and 56.2% of the cholesterol, respectively. Dilution with saline did not alter the latter percentage, whereas dilution with normolipidemic VLDL reduced it showing that LDL-c Plus recognized cholesterol-enriched particles in the d<1.006 Kg/L. Friedewald’s formula also showed a significant, constant bias (-3.1 ± 6.4%) against BQ, whereas the alternative formula did not (0.5 ± 6.1%). Both calculations classified patients better than LDL-c Plus did at NCEP cut-off points. Conclusions In type 2 diabetic patients, LDL-c Plus underestimates LDL-c but measures cholesterol associated to IDL particles in the d<1.006 Kg/L fraction. Although LDLc-Plus might be a better cardiovascular risk estimator when well standardized, at the moment, it does not seem to be superior to calculations.en_US
dc.languageengen_US
dc.relation.ispartofClinical biochemistryen_US
dc.sourceClinical Biochemistry[ISSN 0009-9120],v. 36, p. 177-183en_US
dc.subject32 Ciencias médicasen_US
dc.subject2403 Bioquímicaen_US
dc.subject.otherLDL cholesterolen_US
dc.subject.otherDirect methoden_US
dc.subject.otherType 2 diabetes mellitusen_US
dc.subject.otherVLDen_US
dc.subject.otherLIDLen_US
dc.titleThe effect of VLDL particles on the accuracy of a direct LDL-cholesterol method in type 2 diabetic patientsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/S0009-9120(03)00006-7en_US
dc.identifier.scopus0242500471-
dc.contributor.authorscopusid7401456520-
dc.contributor.authorscopusid6603122935-
dc.contributor.authorscopusid6701846436-
dc.contributor.authorscopusid7402509742-
dc.contributor.authorscopusid7005297613-
dc.description.lastpage183en_US
dc.description.firstpage177en_US
dc.relation.volume36en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages7en_US
dc.utils.revisionen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr1,825-
dc.description.jcrqQ2-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Diabetes y endocrinología aplicada-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-7663-9308-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameWägner, Anna Maria Claudia-
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