Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/52033
Campo DC | Valor | idioma |
---|---|---|
dc.contributor.author | Wägner, Ana María | en_US |
dc.contributor.author | Zapico, Edgar | en_US |
dc.contributor.author | Bonet, Rosa | en_US |
dc.contributor.author | Pérez, Antonio | en_US |
dc.contributor.author | Ordóñez-Llanos, Jordi | en_US |
dc.date.accessioned | 2018-11-25T16:52:44Z | - |
dc.date.available | 2018-11-25T16:52:44Z | - |
dc.date.issued | 2003 | en_US |
dc.identifier.issn | 0009-9120 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/52033 | - |
dc.description.abstract | Objective To assess the accuracy of the direct method LDL-c Plus, in type 2 diabetic patients. Methods LDL-c Plus was measured in 64 consecutive samples of type 2 diabetic patients and compared with betaquantification (BQ), Friedewald’s and an alternative formula. LDL-c Plus was also measured in the VLDL (d<1.006 Kg/L) fraction of these samples and in total serum and the VLDL fraction of a phenotype III patient, before and after diluting it with saline or VLDL from normolipidemic subjects. Results LDL-c Plus showed a significant, constant bias (-8.5 ± 5.6%) against BQ which correlated with VLDL-cholesterol/total triglyceride ratio (r = 0.760, p < 0.0005); bias decreased to zero when the ratio increased. In the VLDL fraction of the diabetic patients and the phenotype III patient LDL-c Plus measured 20.7 ± 11.6% and 56.2% of the cholesterol, respectively. Dilution with saline did not alter the latter percentage, whereas dilution with normolipidemic VLDL reduced it showing that LDL-c Plus recognized cholesterol-enriched particles in the d<1.006 Kg/L. Friedewald’s formula also showed a significant, constant bias (-3.1 ± 6.4%) against BQ, whereas the alternative formula did not (0.5 ± 6.1%). Both calculations classified patients better than LDL-c Plus did at NCEP cut-off points. Conclusions In type 2 diabetic patients, LDL-c Plus underestimates LDL-c but measures cholesterol associated to IDL particles in the d<1.006 Kg/L fraction. Although LDLc-Plus might be a better cardiovascular risk estimator when well standardized, at the moment, it does not seem to be superior to calculations. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Clinical biochemistry | en_US |
dc.source | Clinical Biochemistry[ISSN 0009-9120],v. 36, p. 177-183 | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.subject | 2403 Bioquímica | en_US |
dc.subject.other | LDL cholesterol | en_US |
dc.subject.other | Direct method | en_US |
dc.subject.other | Type 2 diabetes mellitus | en_US |
dc.subject.other | VLD | en_US |
dc.subject.other | LIDL | en_US |
dc.title | The effect of VLDL particles on the accuracy of a direct LDL-cholesterol method in type 2 diabetic patients | en_US |
dc.type | info:eu-repo/semantics/article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/S0009-9120(03)00006-7 | en_US |
dc.identifier.scopus | 0242500471 | - |
dc.contributor.authorscopusid | 7401456520 | - |
dc.contributor.authorscopusid | 6603122935 | - |
dc.contributor.authorscopusid | 6701846436 | - |
dc.contributor.authorscopusid | 7402509742 | - |
dc.contributor.authorscopusid | 7005297613 | - |
dc.description.lastpage | 183 | en_US |
dc.description.firstpage | 177 | en_US |
dc.relation.volume | 36 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.description.numberofpages | 7 | en_US |
dc.utils.revision | Sí | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.jcr | 1,825 | - |
dc.description.jcrq | Q2 | - |
dc.description.scie | SCIE | - |
item.grantfulltext | none | - |
item.fulltext | Sin texto completo | - |
crisitem.author.dept | GIR IUIBS: Diabetes y endocrinología aplicada | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Médicas y Quirúrgicas | - |
crisitem.author.orcid | 0000-0002-7663-9308 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Wägner, Anna Maria Claudia | - |
Colección: | Artículos |
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