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http://hdl.handle.net/10553/52010
Title: | Designing and implementing sample and data collection for an international genetics study: The Type 1 Diabetes Genetics Consortium (T1DGC) | Authors: | Hilner, Joan E. Perdue, Letitia H. Sides, Elizabeth G. Pierce, June J. Wägner, Ana M. Aldrich, Alan Loth, Amanda Albret, Lotte Wagenknecht, Lynne E. Nierras, Concepcion Akolkar, Beena Baskerville, Tracey Bautista, Nines Bhatia, Eesh Bhatia, Vijayalakshmi Bin Hasan, Kamaruzaman Bonnici, Francois Brodnicki, Thomas Browning, Brian Cameron, Fergus Chaichanwatanakul, Katharee To Cheung, Pik Colman, Peter Cotterill, Andrew Couper, Jenny Crock, Patricia Cutfield, Ric Davis, Tim Dixon, Paul Donaghue, Kim Dowling, Katrina Drury, Paul Dye, Sarah Gellert, Shane Abdul Ghani, Rohana Greer, Ristan Han, Xueyao Harrison, Len Homatopoulos, Nick Ji, Linong Jones, Tim Kah Yin, Loke Azmi Kamaruddin, Nor Kanga, Uma Kanungo, Alok Kaur, Gurvinder Kek, Betty Knowles, Simon Krebs, Jeremy Kumar, Neeraj Lee, Yann Jinn Li, Xiaoying Liktimaskul, Supawadee Lloyd, Margaret Louey, Anthony Mehra, Narinder Merriman, Tony Min, Liu Morahan, Grant Moses, Robert Mraz, Grant Murphy, Rinki Nicholson, Ian Panelo, Araceli Poh, Perlita Price, Gareth Ratnam, Nirubasini Sanjeevi, Carani Sedimbi, Saikiran Shen, Shuixian Siok Ying, Goh Tait, Brian Tandon, Nikhil Thomas, Allison Varney, Mike Weerakulwattana, Praewvarin Willis, Jinny Abang Akwo, Elvis Ampudia-Blasco, Francisco Argente, Jesus Avbelj, Magdalena Babadjanova, Gulja Badenhoop, Klaus Battelino, Tadej Beilhack, Georg Bergholdt, Regine Bingley, Polly Boehm, Bernhard Bolidson, Jo Brismar, Kerstin Brorsson, Caroline Carlson, Joyce Castano, Luis Chandler, Kyla Cherubini, Valentino Cinek, Ondrej |
UNESCO Clasification: | 32 Ciencias médicas 320102 Genética clínica |
Keywords: | Trial Objectives Challenges Linkage Loci |
Issue Date: | 2010 | Journal: | Clinical Trials | Abstract: | Background and Purpose The Type 1 Diabetes Genetics Consortium (T1DGC) is an international project whose primary aims are to: (a) discover genes that modify type 1 diabetes risk; and (b) expand upon the existing genetic resources for type 1 diabetes research. The initial goal was to collect 2500 affected sibling pair (ASP) families worldwide. Methods T1DGC was organized into four regional networks (Asia-Pacific, Europe, North America, and the United Kingdom) and a Coordinating Center. A Steering Committee, with representatives from each network, the Coordinating Center, and the funding organizations, was responsible for T1DGC operations. The Coordinating Center, with regional network representatives, developed study documents and data systems. Each network established laboratories for: DNA extraction and cell line production; human leukocyte antigen genotyping; and autoantibody measurement. Samples were tracked from the point of collection, processed at network laboratories and stored for deposit at National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) Central Repositories. Phenotypic data were collected and entered into the study database maintained by the Coordinating Center. Results T1DGC achieved its original ASP recruitment goal. In response to research design changes, the T1DGC infrastructure also recruited trios, cases, and controls. Results of genetic analyses have identified many novel regions that affect susceptibility to type 1 diabetes. T1DGC created a resource of data and samples that is accessible to the research community. Limitations Participation in T1DGC was declined by some countries due to study requirements for the processing of samples at network laboratories and/or final deposition of samples in NIDDK Central Repositories. Re-contact of participants was not included in informed consent templates, preventing collection of additional samples for functional studies. Conclusions T1DGC implemented a distributed, regional network structure to reach ASP recruitment targets. The infrastructure proved robust and flexible enough to accommodate additional recruitment. T1DGC has established significant resources that provide a basis for future discovery in the study of type 1 diabetes genetics. | URI: | http://hdl.handle.net/10553/52010 | ISSN: | 1740-7745 | DOI: | 10.1177/1740774510373497 | Source: | Clinical Trials[ISSN 1740-7745],v. 7(1), p. S5-S32 (Agosto 2010) |
Appears in Collections: | Artículos |
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