Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/51927
Campo DC Valoridioma
dc.contributor.authorSmolarek, Dorota
dc.contributor.authorHattab, Claude
dc.contributor.authorHassanzadeh-Ghassabeh, Gholamreza
dc.contributor.authorCochet, Sylvie
dc.contributor.authorGutierrez, Carlos
dc.contributor.authorDe Brevern, Alexandre G.
dc.contributor.authorUdomsangpetch, Rachanee
dc.contributor.authorPicot, Julien
dc.contributor.authorGrodecka, Magdalena
dc.contributor.authorWasniowska, Kazimiera
dc.contributor.authorMuyldermans, Serge
dc.contributor.authorColin, Yves
dc.contributor.authorLe Van Kim, Caroline
dc.contributor.authorCzerwinski, Marcin
dc.contributor.authorBertrand, Olivier
dc.contributor.otherGutierrez, Carlos
dc.contributor.otherde Brevern, Alexandre
dc.contributor.otherCochet, sylvie
dc.contributor.otherMuyldermans, Serge
dc.contributor.othercolin, yves
dc.contributor.otherWasniowska, Kazimiera
dc.contributor.otherCzerwinski, Marcin
dc.contributor.otherle van kim, caroline
dc.date.accessioned2018-11-25T05:29:34Z-
dc.date.available2018-11-25T05:29:34Z-
dc.date.issued2010
dc.identifier.issn1420-682X
dc.identifier.urihttp://hdl.handle.net/10553/51927-
dc.description.abstractFy blood group antigens are carried by the Duffy antigen receptor for chemokines (DARC), a red cells receptor for Plasmodium vivax broadly implicated in human health and diseases. Recombinant VHHs, or nanobodies, the smallest intact antigen binding fragment derivative from the heavy chain-only antibodies present in camelids, were prepared from a dromedary immunized against DARC N-terminal extracellular domain and selected for DARC binding. A described VHH, CA52, does recognize native DARC on cells. It inhibits P. vivax invasion of erythrocytes and displaces interleukin-8 bound to DARC. The targeted epitope overlaps the well-defined DARC Fy6 epitope. K (D) of CA52-DARC equilibrium is sub-nanomolar, hence ideal to develop diagnostic or therapeutic compounds. Immunocapture by immobilized CA52 yielded highly purified DARC from engineered K562 cells. This first report on a VHH with specificity for a red blood cell protein exemplifies VHHs' potentialities to target, to purify, and to modulate the function of cellular markers.
dc.publisher1420-682X
dc.relation.ispartofCellular and Molecular Life Sciences
dc.sourceCellular And Molecular Life Sciences[ISSN 1420-682X],v. 67 (19), p. 3371-3387
dc.subject.otherPlasmodium-Vivax
dc.subject.otherMonoclonal-Antibody
dc.subject.otherHiv-1 Acquisition
dc.subject.otherBinding-Protein
dc.subject.otherMolecular-Basis
dc.subject.otherExpression
dc.subject.otherAntigen/Receptor
dc.subject.otherMalaria
dc.subject.otherCells
dc.subject.otherGene
dc.titleA recombinant dromedary antibody fragment (VHH or nanobody) directed against human Duffy antigen receptor for chemokines
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1007/s00018-010-0387-6
dc.identifier.scopus77956759905
dc.identifier.isi000281668100012
dcterms.isPartOfCellular And Molecular Life Sciences
dcterms.sourceCellular And Molecular Life Sciences[ISSN 1420-682X],v. 67 (19), p. 3371-3387
dc.contributor.authorscopusid23566823200
dc.contributor.authorscopusid6602293547
dc.contributor.authorscopusid25645875200
dc.contributor.authorscopusid6603596774
dc.contributor.authorscopusid7202545218
dc.contributor.authorscopusid6602559505
dc.contributor.authorscopusid7004221779
dc.contributor.authorscopusid36025678300
dc.contributor.authorscopusid16068372800
dc.contributor.authorscopusid55906233400
dc.contributor.authorscopusid7005810441
dc.contributor.authorscopusid7005211769
dc.contributor.authorscopusid7003841661
dc.contributor.authorscopusid7005748467
dc.contributor.authorscopusid56531546900
dc.description.lastpage3387
dc.description.firstpage3371
dc.relation.volume67
dc.type2Artículoes
dc.identifier.wosWOS:000281668100012
dc.contributor.daisngid2496502
dc.contributor.daisngid2360218
dc.contributor.daisngid1654264
dc.contributor.daisngid1159781
dc.contributor.daisngid475608
dc.contributor.daisngid369376
dc.contributor.daisngid235333
dc.contributor.daisngid931814
dc.contributor.daisngid1793613
dc.contributor.daisngid2508043
dc.contributor.daisngid853720
dc.contributor.daisngid90348
dc.contributor.daisngid243062
dc.contributor.daisngid276658
dc.contributor.daisngid347767
dc.contributor.daisngid164048
dc.contributor.daisngid34787553
dc.identifier.investigatorRIDE-2989-2012
dc.identifier.investigatorRIDB-4788-2009
dc.identifier.investigatorRIDI-2721-2015
dc.identifier.investigatorRIDC-6418-2016
dc.identifier.investigatorRIDO-1910-2017
dc.identifier.investigatorRIDNo ID
dc.identifier.investigatorRIDNo ID
dc.identifier.investigatorRIDNo ID
dc.contributor.wosstandardWOS:Smolarek, D
dc.contributor.wosstandardWOS:Hattab, C
dc.contributor.wosstandardWOS:Hassanzadeh-Ghassabeh, G
dc.contributor.wosstandardWOS:Cochet, S
dc.contributor.wosstandardWOS:Gutierrez, C
dc.contributor.wosstandardWOS:de Brevern, AG
dc.contributor.wosstandardWOS:Udomsangpetch, R
dc.contributor.wosstandardWOS:Picot, J
dc.contributor.wosstandardWOS:Grodecka, M
dc.contributor.wosstandardWOS:Wasniowska, K
dc.contributor.wosstandardWOS:Muyldermans, S
dc.contributor.wosstandardWOS:Colin, Y
dc.contributor.wosstandardWOS:Le Van Kim, C
dc.contributor.wosstandardWOS:Czerwinski, M
dc.contributor.wosstandardWOS:Bertrand, O
dc.date.coverdateOctubre 2010
dc.identifier.ulpgces
dc.description.jcr7,047
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Medicina Veterinaria e Investigación Terapéutica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0003-0764-7408-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameGutiérrez Cabrera,Carlos Javier-
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